{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:21:59Z","timestamp":1764937319227,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Epidemiological studies should substantiate the paradigm that endothelial dysfunction contributes to the development of heart failure with preserved ejection fraction (HFpEF). We investigated the association of cardiac remodeling and dysfunction with peripheral vasoreactivity in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 424 individuals, we echocardiographically assessed cardiac structure and function and determined digital vasomotor function by photoplethysmography (PPG) during reactive hyperemia (RH). We regressed echocardiographic indexes and abnormalities on RH ratios averaged for 30\u00a0s time intervals. We derived sex\u2010specific peripheral vasoreactivity profiles from PPG time\u2010series and compared their echocardiographic phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher left ventricular (LV) mass index and lower E\/A ratio and e\u2019 peak and left atrial reservoir strain were independently related to lower RH ratios. Participants with LV hypertrophy or diastolic dysfunction presented significantly lower RH ratios during the 30 to 240s intervals than normal counterparts. Low RH responders (<jats:italic>n<\/jats:italic>\u00a0=\u00a0250) presented higher odds for LV hypertrophy (adjusted OR: 2.60; <jats:italic>p\u00a0<\/jats:italic>=\u00a0.0040) and LV diastolic dysfunction (adjusted OR: 2.66; <jats:italic>p\u00a0<\/jats:italic>=\u00a0.0037) than moderate\u2010to\u2010high responders (<jats:italic>n<\/jats:italic>\u00a0=\u00a0174).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The association between subclinical heart maladaptation and decreased microvascular reactivity supports the involvement of endothelial dysfunction in HFpEF pathogenesis. Time\u2010integrated profiling of microvascular vasoreactivity may enable early detection of HFpEF in the community.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12731","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T19:07:30Z","timestamp":1632769650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Subclinical heart remodeling and dysfunction in relation to peripheral endothelial dysfunction: A general population study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-7692","authenticated-orcid":false,"given":"Nicholas","family":"Cauwenberghs","sequence":"first","affiliation":[{"name":"Research Unit Hypertension and Cardiovascular Epidemiology KU Leuven Department of Cardiovascular Sciences University of Leuven Leuven 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