{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:40:59Z","timestamp":1753879259023,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008810","name":"NSW Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Novel coronavirus disease 2019 (COVID\u201019) has been found to be associated with encephalopathy and brain imaging abnormalities. The identification of incident white matter lesions, known to be associated with cerebral microcirculatory failure and cerebrovascular disease, in COVID\u201019 patients is of clinical and scientific interest. We performed a meta\u2010analysis to investigate the incidence of white matter lesions (WMLs) in hospitalized COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, and the Cochrane Library were searched for studies on brain imaging abnormalities in hospitalized COVID\u201019 patients. The terms used included \u201cwhite matter lesions,\u201d \u201cwhite matter hyperintensity,\u201d \u201cCOVID\u201019,\u201d \u201ccoronavirus,\u201d and \u201cSARS\u2010CoV\u20102.\u201d A random\u2010effects meta\u2010analysis was conducted to obtain a pooled estimate of WML prevalence in hospitalized COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4 eligible studies involving 362 patients (144 with WMLs and 218 without) were included in the meta\u2010analysis. We found the pooled estimate of WML prevalence to be 20% (ES 0.20; 95% CI 0.00\u20130.54; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The estimated pooled prevalence rate of WMLs was approximately 20% in hospitalized COVID\u201019 patients, albeit lower than the crude prevalence rate (39.8%).<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12749","type":"journal-article","created":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T17:18:01Z","timestamp":1644167881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Incidence of white matter lesions in hospitalized COVID\u201019 patients: A meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Aarushi","family":"Rastogi","sequence":"first","affiliation":[{"name":"Global Health Neurology and Translational Neuroscience Laboratory  Sydney NSW Australia"},{"name":"Neurovascular Imaging Laboratory Clinical Sciences Stream Ingham Institute for Applied Medical Research  Sydney NSW Australia"},{"name":"University of New South Wales (UNSW) South Western Sydney Clinical School  Liverpool NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-3628","authenticated-orcid":false,"given":"Sonu Menachem Maimonides","family":"Bhaskar","sequence":"additional","affiliation":[{"name":"Global Health Neurology and Translational Neuroscience Laboratory  Sydney NSW Australia"},{"name":"Neurovascular Imaging Laboratory Clinical Sciences Stream Ingham Institute for Applied Medical Research  Sydney NSW Australia"},{"name":"NSW Brain Clot Bank NSW Health Pathology  Sydney NSW Australia"},{"name":"Department of Neurology and Neurophysiology Comprehensive Stroke Center Liverpool Hospital and South\u2010Western Sydney Local Health District  Sydney NSW Australia"},{"name":"Stroke and Neurology Research Group Ingham Institute for Applied Medical Research  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22906"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.07.014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100037264"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15379"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13519"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39733"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.314531"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14934"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760\u2010021\u201001720\u20103"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3258-72-39"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202422"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201697"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201933"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6610"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027115"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007682"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.1.9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20586"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2006.00047.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.18.20888"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117308"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010116"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.1.81"}],"container-title":["Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/micc.12749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/micc.12749","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/micc.12749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T19:54:03Z","timestamp":1692474843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/micc.12749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,14]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/micc.12749"],"URL":"https:\/\/doi.org\/10.1111\/micc.12749","archive":["Portico"],"relation":{},"ISSN":["1073-9688","1549-8719"],"issn-type":[{"type":"print","value":"1073-9688"},{"type":"electronic","value":"1549-8719"}],"subject":[],"published":{"date-parts":[[2022,2,14]]},"assertion":[{"value":"2021-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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