{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:05:03Z","timestamp":1781730303926,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T00:00:00Z","timestamp":1645315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/03756\u20104"],"award-info":[{"award-number":["2015\/03756\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303422\/2015\u20107"],"award-info":[{"award-number":["303422\/2015\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multisystem inflammatory syndrome in children (MIS\u2010c) is associated with severe cardiovascular impairment and eventually death. Pathophysiological mechanisms involved in myocardial injury were scarcely investigated, and cardiovascular outcomes are uncertain. Autopsy studies suggested that microvascular dysfunction may be relevant to LV impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to evaluate segmental LV longitudinal strain by 2DST echocardiography and myocardial flow reserve (MFR) by 13\u00a0N\u2010ammonia PET\u2010CT, in <jats:bold>six<\/jats:bold> surviving MIS\u2010c patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Each patient generated 34 LV segments for combined 2DST and MRF analysis. MFR was considered abnormal when &lt;2, borderline when between 2 and 2.5 and normal when &gt;2.5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From July 2020 to February 2021, six patients were admitted with MIS\u2010c: three males, aged 9.3 (6.6\u201315.7) years. Time from admission to the follow\u2010up visit was 6.05 (2\u201310.3) months. Although all patients were asymptomatic and LV EF was \u226555%, 43\/102 (42.1%) LV segments showed MFR &lt;2.5. There was a modest positive correlation between segmental peak systolic longitudinal strain and MFR: <jats:italic>r<\/jats:italic>\u00a0=\u00a0.36, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03 for basal segments; <jats:italic>r<\/jats:italic>\u00a0=\u00a0.41, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.022 for mid segments; <jats:italic>r<\/jats:italic>\u00a0=\u00a0.42, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.021 for apical segments. Median peak systolic longitudinal strain was different among MRF categories: 18% (12%\u201324%) for abnormal, 18.5% (11%\u201335%) for borderline, and 21% (12%\u201332%) for normal MFR (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We provided preliminary evidence that surviving MIS\u2010c patients may present subclinical impairment of myocardial microcirculation. Segmental cardiac strain assessment 2DST seems useful for MIS\u2010c cardiovascular follow\u2010up, given its good correlation with 13\u00a0N\u2010ammonia PET\u2010CT derived MFR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12750","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T07:51:42Z","timestamp":1644565902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Segmental cardiac strain assessment by two\u2010dimensional speckle\u2010tracking echocardiography in surviving MIS\u2010c patients: Correlations with myocardial flow reserve (MFR) by 13 N\u2010ammonia PET\u2010CT"],"prefix":"10.1111","volume":"29","author":[{"given":"Gabriela Nunes","family":"Leal","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Ecocardiografia Pedi\u00e1trica Instituto da Crian\u00e7a e do Adolescente Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo\u2010SP Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Astley","sequence":"additional","affiliation":[{"name":"Grupo de Pesquisa em Fisiologia Aplicada e Nutri\u00e7\u00e3o Universidade de S\u00e3o Paulo  S\u00e3o Paulo\u2010SP Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Santos","family":"Lima","sequence":"additional","affiliation":[{"name":"Departamento de Radiologia e Oncologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo\u2010SP Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6822-0304","authenticated-orcid":false,"given":"Maria de F\u00e1tima Rodrigues","family":"Diniz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ecocardiografia Pedi\u00e1trica Instituto da Crian\u00e7a e do Adolescente Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  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