{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:52:02Z","timestamp":1790272322603,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010628","name":"Universidad de La Sabana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate the association between serum albumin levels and microcirculation changes, glycocalyx degradation, and the clinical outcomes of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational, prospective study in children with sepsis. The primary outcome was the association between hypoalbuminemia and microcirculation disorders, endothelial activation and glycocalyx degradation using a perfused boundary region (PBR) (abnormal &gt;2.0\u2009\u03bcm on sublingual video microscopy) or plasma biomarkers (syndecan\u20101, angiopoietin\u20102).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 125 patients with sepsis were included. The median age was 2.0\u2009years (IQR 0.5\u201312.5). Children with hypoalbuminemia had more abnormal microcirculation with a higher PBR (2.16\u2009\u03bcm [IQR 2.03\u20132.47] vs. 1.92 [1.76\u20132.28];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01) and more 4\u20136\u2009\u03bcm capillaries recruited (60% vs. 40%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.04). The low albumin group that had the worst PBR had the most 4\u20136\u2009\u03bcm capillaries recruited (rho 0.29;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01), 48% higher Ang\u20102 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.04), worse annexin A5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and no syndecan\u20101 abnormalities (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.21). Children with hypoalbuminemia and a greater percentage of blood volume in their capillaries needed mechanical ventilation more often (56.3% vs. 43.7%; aOR 2.01 95% CI 1.38\u20133.10:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In children with sepsis, an association was found between hypoalbuminemia and microcirculation changes, vascular permeability, and greater endothelial glycocalyx degradation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.12829","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:19:16Z","timestamp":1693228756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The association between hypoalbuminemia and microcirculation, endothelium, and glycocalyx disorders in children with sepsis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2874-2949","authenticated-orcid":false,"given":"Jaime","family":"Fern\u00e1ndez\u2010Sarmiento","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine and Pediatrics Universidad de La Sabana Fundaci\u00f3n Cardioinfantil\u2010Instituto de Cardiolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-0563","authenticated-orcid":false,"given":"Ricardo","family":"Hern\u00e1ndez\u2010Sarmiento","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Pediatrics Universidad de La Sabana Fundaci\u00f3n Cardioinfantil\u2010Instituto de Cardiolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Paula","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Pediatrics Universidad de La Sabana Fundaci\u00f3n Cardioinfantil\u2010Instituto de Cardiolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Barrera","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Pediatrics Universidad de La Sabana Fundaci\u00f3n Cardioinfantil\u2010Instituto de Cardiolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Castilla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fundaci\u00f3n Cardioinfantil\u2010Instituo de Cardiolog\u00eda Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Duque","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Pediatrics Universidad de La Sabana Fundaci\u00f3n Cardioinfantil\u2010Instituto de Cardiolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002198"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/08850666211054444"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.726949"},{"issue":"1","key":"e_1_2_13_5_1","first-page":"1","article-title":"Glycocalyx and sepsis\u2010induced alterations in vascular permeability","volume":"18","author":"Chelazzi C","year":"2015","journal-title":"Crit Care"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002266"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2013.08.007"},{"issue":"6","key":"e_1_2_13_8_1","first-page":"1773","article-title":"Fine 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