{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:12:08Z","timestamp":1792523528500,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Diabetic foot ulcer (DFU) is a severe complication with high mortality. High plantar pressure and poor microcirculation are considered main causes of DFU. The specific aims were to provide a novel technique for real\u2010time measurement of plantar skin blood flow (SBF) under walking\u2010like pressure stimulus and delineate the first plantar metatarsal head dynamic microcirculation characteristics because of life\u2010like loading conditions in healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty young healthy participants (14 male and 6 female) were recruited. The baseline (i.e., unloaded) SBF of soft tissue under the first metatarsal head were measured using laser Doppler flowmetry (LDF). A custom\u2010made machine was utilized to replicate daily walking pressure exertion for 5\u2009min. The exerted plantar force was adjusted from 10\u2009N (127.3\u2009kPa) to 40\u2009N (509.3\u2009kPa) at an increase of 5\u2009N (63.7\u2009kPa). Real\u2010time SBF was acquired using the LDF. After each pressure exertion, postload SBF was measured for comparative purposes. Statistical analysis was performed using the R software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All levels of immediate\u2010load and postload SBF increased significantly compared with baseline values. As the exerted load increased, the postload and immediate\u2010load SBF tended to increase until the exerted load reached 35\u2009N (445.6\u2009kPa). However, in immediate\u2010load data, the increasing trend tended to level off as the exerted pressure increased from 15\u2009N (191.0\u2009kPa) to 25\u2009N (318.3\u2009kPa). For postload and immediate\u2010load SBF, they both peaked at 35\u2009N (445.6\u2009kPa). However, when the exerted force exceeds 35\u2009N (445.6\u2009kPa), both the immediate\u2010load and postload SBF values started to decrease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study offered a novel real\u2010time plantar soft tissue microcirculation measurement technique under dynamic conditions. For the first metatarsal head of healthy people, 20\u2009N (254.6\u2009kPa)\u2010plantar pressure has a fair microcirculation stimulus compared with higher pressure. There might be a pressure threshold at 35\u2009N (445.6\u2009kPa) for the first metatarsal head, and soft tissue microcirculation may decrease when local pressure exceeds it.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12860","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T17:09:48Z","timestamp":1717607388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dynamic Microcirculation Characteristics of Plantar Skin Under Metatarsal Head of Human Foot in Response to Life\u2010Like Pressure Stimulus"],"prefix":"10.1111","volume":"31","author":[{"given":"Zhenming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Huashan Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Technology, Academy for Engineering and Technology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong\u2010Gang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Huashan Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Technology, Academy for Engineering and Technology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Huashan Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Huashan Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Huashan Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Huashan Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Huashan Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0141076816688346"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67696-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.8.1339"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/ab2058"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2018.12.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1076445"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.05.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00973-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.11.038"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-160239"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-018-1836-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-180459"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3269"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734620915360"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04437-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2013.05.004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/e22111288"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physa.2013.06.007"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6208499"},{"key":"e_1_2_9_22_1","volume-title":"Mann's Surgery of the Foot and Ankle","author":"Coughlin M. 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