{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:05:15Z","timestamp":1792026315613,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007207","name":"Toray Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009158","name":"Kawasaki Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009158","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Endothelial dysfunction plays an important role in the pathogenesis of chronic kidney disease. Prostacyclin (PGI<jats:sub>2<\/jats:sub>), an endothelial cell\u2010produced endogenous prostaglandin, plays a crucial role in maintaining endothelial function. However, its effects on intestinal microcirculation and barrier function are not fully understood. We hypothesized that PGI<jats:sub>2<\/jats:sub> improves intestinal microcirculation and barrier function via endothelial protective effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ICR and ICGN (a spontaneous nephrotic model) mice were used in this study. Intestinal microcirculation was visualized in\u00a0vivo to investigate PGI<jats:sub>2<\/jats:sub> effects. Beraprost served as PGI<jats:sub>2<\/jats:sub>. PGI<jats:sub>2<\/jats:sub> administration spanned 4\u2009weeks, following which we assessed its influence on intestinal endothelial, intestinal barrier, and renal functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We visualized intestinal microcirculation and endothelial glycocalyx in the intestinal blood vessels. Beraprost administration induced a 1.2\u2010fold dilatation of the vascular diameter of the small intestine. Intestinal blood flow in ICGN mice was significantly reduced compared that in ICR mice but improved with beraprost administration. ICGN mice exhibited reduced serum albumin levels, decreased ambulation, an imbalance in intestinal reactive oxygen species (ROS)\/nitric oxide (NO), and impaired tight junctions; all were ameliorated by beraprost administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Beraprost improves intestinal microcirculation and barrier function by ameliorating ROS\/NO imbalances, thereby reducing physical inactivity during renal failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12889","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T16:53:56Z","timestamp":1727715236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Beraprost on Intestinal Microcirculation and Barrier Function in a Mouse Model of Renal Failure"],"prefix":"10.1111","volume":"31","author":[{"given":"Akira","family":"Hirano","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-3869","authenticated-orcid":false,"given":"Hiroyuki","family":"Kadoya","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Kawasaki Medical School  Kurashiki Okayama Japan"},{"name":"Department of General Geriatric Medicine Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Takasu","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Kajimoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Tatsugawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-8392","authenticated-orcid":false,"given":"Takumi","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Toray Industries, Inc.  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