{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:40:31Z","timestamp":1753879231768,"version":"3.41.2"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL088105"],"award-info":[{"award-number":["HL088105"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In conduit arteries, aging and hypertension are associated with stiffening characterized by increased cytoskeletal F\u2010actin and endothelial dysfunction. Herein, we determined if this also happens at the level of the resistance vasculature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively compared the mechanical and structural characteristics of small arteries isolated from older hypertensive and younger normotensive (64.7\u2009\u00b1\u20092.8 vs. 32.1\u2009\u00b1\u20091.9\u2009years old) human subjects. The intersection of aging and hypertension was studied in small mesenteric arteries from old (88\u2009weeks of age) spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) normotensive rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Arteries from older hypertensive subjects were stiffer and had more F\u2010actin, relative to those from younger normotensives. Comparatively, arteries from old SHRs showed reduced stiffness and increased vasodilation to sodium nitroprusside without changes in F\u2010actin. Matrix metalloproteinase\u20102 (MMP\u20102) and \u20109 (MMP\u20109) were increased in the SHR arteries and exposure of naive arteries to exogenous MMP\u20102 and MMP\u20109 augmented responsiveness to sodium nitroprusside and adenosine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, resistance arteries from old SHRs are softer and vasodilate more to exogenous nitric oxide than those of WKY rats. This improved endothelial\u2010independent vasodilation is associated with an increased vascular expression of MMP\u20102 and MMP\u20109. We further conclude that aging and hypertension effects on the microcirculation may vary between species and vascular beds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.70004","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T05:00:14Z","timestamp":1739854814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Small Arteries From Old Spontaneously Hypertensive Rats Exhibit Enhanced Endothelium\u2010Independent Vasodilatory Capacity and Reduced Stiffness"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-383X","authenticated-orcid":false,"given":"Francisco I.","family":"Ramirez\u2010Perez","sequence":"first","affiliation":[{"name":"NextGen Precision Health University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Jurrissen","sequence":"additional","affiliation":[{"name":"NextGen Precision Health University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-8799","authenticated-orcid":false,"given":"Marc A.","family":"Augenreich","sequence":"additional","affiliation":[{"name":"NextGen Precision Health University of Missouri  Columbia Missouri USA"},{"name":"Department of Nutrition and Exercise Physiology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5252-375X","authenticated-orcid":false,"given":"Jorge A.","family":"Castorena\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Tulane University  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Morales\u2010Quinones","sequence":"additional","affiliation":[{"name":"NextGen Precision Health University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Foote","sequence":"additional","affiliation":[{"name":"NextGen Precision Health University of Missouri  Columbia Missouri USA"},{"name":"Department of Medical Pharmacology and Physiology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Nourian","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology and Physiology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4207-3422","authenticated-orcid":false,"given":"Olubodun M.","family":"Lateef","sequence":"additional","affiliation":[{"name":"NextGen Precision Health University of Missouri  Columbia Missouri USA"},{"name":"Department of Medical Pharmacology and Physiology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natnicha","family":"Imkaew","sequence":"additional","affiliation":[{"name":"NextGen Precision Health University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology and Physiology University of Missouri  Columbia Missouri USA"},{"name":"Dalton Cardiovascular Research Center University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology and Physiology University of Missouri  Columbia Missouri USA"},{"name":"Dalton Cardiovascular Research Center University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald A.","family":"Meininger","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology and Physiology University of Missouri  Columbia Missouri USA"},{"name":"Dalton Cardiovascular Research Center University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Padilla","sequence":"additional","affiliation":[{"name":"NextGen Precision Health University of Missouri  Columbia Missouri USA"},{"name":"Department of Nutrition and Exercise Physiology University of Missouri  Columbia Missouri USA"},{"name":"Dalton Cardiovascular Research Center University of Missouri  Columbia Missouri USA"},{"name":"Harry S. 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