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To do so, we must first understand the underlying mechanisms that contribute to the development of clinical lymphedema, which can be caused by a myriad of factors, including genetic mutations, infectious agents, and cancer treatments. Animal models are essential to study the pathogenesis of clinical lymphedema and to develop therapeutic interventions. Many animal models mimic the various aspects of lymphatic dysfunction and lymphedema seen in humans, and some species better represent different aspects or causes of lymphedema. However, no single model perfectly recapitulates human disease in a cost\u2010 and time\u2010efficient manner; therefore, findings should be verified in multiple models and multiple species. In doing so, researchers will increase the likelihood of collecting rigorous, reliable data that could be effectively and efficiently translated into the clinic. This review explores genetic, infectious, and surgical animal models of lymphatic dysfunction and lymphedema and describes how these models can be used to understand clinical forms of lymphedema. Collectively, this information can provide valuable insight for the translational study of lymphatic diseases.<\/jats:p>","DOI":"10.1111\/micc.70009","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T03:42:03Z","timestamp":1747885323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Relevance of Animal Models of Lymphatic Dysfunction and Lymphedema"],"prefix":"10.1111","volume":"32","author":[{"given":"Pritam Saha","family":"Podder","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy, University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasree","family":"Bhadra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8003-9866","authenticated-orcid":false,"given":"Soumiya","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy, University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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