{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:49:52Z","timestamp":1782100192698,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Neuropeptide Y (NPY) is a sympathetic co\u2010transmitter that mediates vasoconstriction. However, there is evidence that it may also mediate dilation through a nitric oxide (NO)\u2010dependent mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We used a swine model to examine how NPY influences cerebral vascular regulation and hypothesized that NPY would elicit both vasoconstrictor and vasodilatory effects, and that such effects would be modulated partially by NO signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Briefly, cerebral perfusion and blood pressure were monitored during intracarotid saline or NPY infusion (0.1\u2009\u03bcg\/kg) in the presence and absence of NO synthase (NOS) inhibition (\n                      <jats:italic>N<\/jats:italic>\n                      <jats:sup>G<\/jats:sup>\n                      \u2010nitro\u2010l\u2010arginine methyl ester; 0.35\u2009mg\/kg\/min). Separately, Y1 receptor distribution (immunohistochemistry) and vasomotor responses to intra\u2010 and extraluminal NPY under control and NOS inhibition conditions were examined in isolated arteries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intracarotid NPY infusions elicited transient dilation that was blocked by NOS inhibition. In isolated pial arteries, distinct populations of NPY\u2010Y1 receptors were observed on both the vascular smooth muscle (VSM) and endothelium. Extraluminal application of NPY elicited vasoconstriction, while intraluminal delivery elicited vasodilation. NOS inhibition enhanced the magnitude of vasoconstriction in isolated pial arteries. Endothelial denudation, Y1 receptor antagonism, and NOS inhibition each blunted NPY\u2010induced vasodilation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data suggest both vasoconstrictor and vasodilatory effects of NPY are modulated partially by NO signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.70016","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:18:56Z","timestamp":1751069936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Modulatory Role of Nitric Oxide on the Vasomotor Actions of\n                    <scp>NPY<\/scp>\n                    in Porcine Cerebral Arteries"],"prefix":"10.1111","volume":"32","author":[{"given":"Gabriela","family":"Delgado","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron J.","family":"Morse","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanna","family":"Barlage","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Harold","family":"Laughlin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Emter","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-3485","authenticated-orcid":false,"given":"Erika M.","family":"Boerman","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology and Pharmacology University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Padilla","sequence":"additional","affiliation":[{"name":"Dalton Cardiovascular Research Center University of Missouri  Columbia Missouri USA"},{"name":"Department of Nutrition and Exercise Physiology University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey R.","family":"Tomczak","sequence":"additional","affiliation":[{"name":"College of Kinesiology University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Dylan","family":"Olver","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Saskatchewan 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