{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:27:19Z","timestamp":1789064839509,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>During skin inflammation, inhibition of adhesion of regulatory T cells (Tregs) to the dermal microvascular endothelium leads to exacerbation of inflammation, evidence that the dermal endothelium is a key target of the anti\u2010inflammatory actions of Tregs. The aim of this study was to investigate the capacity of Tregs to control the expression of endothelial adhesion molecules in inflamed and resting skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Treg function was assessed in a two\u2010challenge contact hypersensitivity (CHS) model, measuring dermal adhesion molecule expression via imaging of cleared skin. Treg depletion was achieved using\n                      <jats:italic>Foxp3<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>DTR<\/jats:italic>\n                      <\/jats:sup>\n                      mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CHS induced upregulation of E\u2010selectin and ICAM\u20101 but not P\u2010selectin and VCAM\u20101. Elimination of Tregs following CHS challenge resulted in exacerbated skin inflammation and enhanced expression of E\u2010selectin, P\u2010selectin and ICAM\u20101 in the dermal microvasculature. Multiphoton imaging revealed that at this phase of the response, Tregs were enriched near blood vessels and underwent dynamic migration adjacent to the microvasculature. Additionally, in skin that was not undergoing hapten challenge, absence of Tregs also resulted in upregulation of E\u2010selectin and ICAM\u20101 in skin vessels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These observations demonstrate that the microvascular endothelium is a target of the anti\u2010inflammatory actions of Tregs in the skin, both during CHS and in steady\u2010state skin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.70017","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T12:44:44Z","timestamp":1751201084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Regulatory T Cells Control Vascular Adhesion Molecule Expression in Skin Under Inflammatory and Homeostatic Conditions"],"prefix":"10.1111","volume":"32","author":[{"given":"M. Ursula","family":"Norman","sequence":"first","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine Monash Medical Centre  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Lim","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine Monash Medical Centre  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine Monash Medical Centre  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pam","family":"Hall","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine Monash Medical Centre  Clayton Victoria 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