{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T16:35:54Z","timestamp":1769704554294,"version":"3.49.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM135007\u201004S1"],"award-info":[{"award-number":["P20GM135007\u201004S1"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM135007"],"award-info":[{"award-number":["P20 GM135007"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["2R01NS093289\u201010"],"award-info":[{"award-number":["2R01NS093289\u201010"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We examined if exposure to experimental preeclampsia (ePE) impacts vascular permeability and reactivity of posterior cerebral arteries (PCAs) in adult offspring, and if maternal antioxidant treatment prevents these effects in adult male and female offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Offspring (F1) from rats with Normal pregnancy (NormPreg_F1), ePE_F1 and ePE treated with apocynin (ePE\u2009+\u2009apo_F1) were weighed at p24, p31, p38, and p45. Maternal apocynin was administered weekly in drinking water at a dose of \u223c24\u2009mg\/kg (3\u2009mM) on gestational days 11\u201320. Blood\u2013brain barrier (BBB) permeability, structure and function of PCAs were measured from male and female adult offspring (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098\/group, 12\u201329\u2009weeks). Circulating inflammatory factors were measured by multiplex array.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Male ePE_F1 had smaller body weights than male NormPreg_F1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) at all ages which was prevented by maternal apocynin. Female ePE_F1 body weights were less only at p24 which was prevented by maternal apocynin. PCAs from male ePE_F1 had increased BBB permeability versus male NormPreg_F1 which was prevented by apocynin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). These changes were not seen in female ePE_F1s. Maternal ePE did not affect PCA reactivity to inward potassium rectifier channel or voltage\u2010operated calcium channel activation, nor reactivity to L\u2010NAME and sodium nitroprusside. There were little differences in plasma inflammatory factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ePE exposure had long\u2010term consequences on the cerebral circulation of adult male offspring. Understanding the underlying mechanism by which PE adversely impacts the brain of offspring may lead to the prevention of cognitive decline and stroke in adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.70044","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:22:23Z","timestamp":1765977743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Apocynin During Experimental Preeclampsia Prevents\n                    <scp>BBB<\/scp>\n                    Permeability and Increased Vascular Tone of Cerebral Arteries in Male but Not Female Rat Adult Offspring"],"prefix":"10.1111","volume":"33","author":[{"given":"Milena","family":"Esposito","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences University of Vermont Larner College of Medicine  Burlington Vermont USA"},{"name":"Department of Biology, Ecology and Earth Science University of Calabria, Arcavacata di Rende  Calabria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M.","family":"Tremble","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Vermont Larner College of Medicine  Burlington Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn J.","family":"Cipolla","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Vermont Larner College of Medicine  Burlington Vermont USA"},{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences University of Vermont Larner College of Medicine  Burlington Vermont USA"},{"name":"Department of Pharmacology University of Vermont Larner College of Medicine  Burlington Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2016-009"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16683"},{"issue":"5","key":"e_1_2_12_4_1","article-title":"Short\u2010 and Long\u2010Term Outcomes of Preeclampsia in Offspring: Review of the Literature","volume":"10","author":"Koulouraki S.","year":"2023","journal-title":"Children (Basel)"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.198366"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.06.013"},{"issue":"3","key":"e_1_2_12_7_1","first-page":"e275","article-title":"Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism","volume":"9","author":"Lu H. Q.","year":"2019","journal-title":"AJP Reports"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12753"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2011.01257.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2014.09.005"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02634.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0216-5"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062123"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-018-0961-4"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00076.2018"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9060-7"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01513"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111491"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.538025"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00430-6"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00375"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.035796"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.034"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.584135"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.79.2.0256"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0322-2"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13408"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.162"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0297-y"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20164051"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221121872"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21756"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.924908"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.650498"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2013.12.001"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13121462"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.889918"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.10.006"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000021"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-222216"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221080092"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02363917"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00630.2009"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.02.003"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp223"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5064"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.02.004"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4640"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-024-01574-z"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2013.56.3.107"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120147"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.124.23373"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.11.013"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101815"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-99"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1976.tb11804.x"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181b4f736"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000151117"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.48"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.1097"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:25:1:15"}],"container-title":["Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/micc.70044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/micc.70044","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/micc.70044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T06:50:17Z","timestamp":1769669417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/micc.70044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/micc.70044"],"URL":"https:\/\/doi.org\/10.1111\/micc.70044","archive":["Portico"],"relation":{},"ISSN":["1073-9688","1549-8719"],"issn-type":[{"value":"1073-9688","type":"print"},{"value":"1549-8719","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]},"assertion":[{"value":"2025-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70044"}}