{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:04:19Z","timestamp":1785751459089,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salt\u2010sensitive hypertension (SSH) is associated with phenotypic changes in vascular smooth muscle cells (VSMCs). This study aimed to investigate the role of interleukin\u201017 (IL\u201017) in SSH and its impact on VSMC phenotype, focusing on the PI3K\/AKT signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In vivo, an SSH rat model was established. Systolic blood pressure (SBP) was monitored, and mesenteric artery tissues were collected for ex\u00a0vivo histological and immunohistochemical analysis. In\u00a0vitro, VSMCs were isolated from the arteries. Lentiviral vectors were used to knock down or overexpress IL\u201017 in these cells. Cell viability, migration, and invasion were assessed using CCK\u20108, scratch, and Transwell assays, respectively. Phosphorylation status was analyzed using a RayBiotech antibody array. Protein expression and phosphorylation levels were analyzed by Western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In vivo, SSH model rats developed hypertension and exhibited VSMC phenotypic transformation in mesenteric arteries. In\u00a0vitro, VSMCs from SSH model rats showed elevated IL\u201017 expression. Knockdown of IL\u201017 in these cells suppressed their hyper\u2010proliferative, migratory, and invasive phenotype and reversed the expression changes of contractile (\u03b1\u2010actin and calponin) and synthetic (osteopontin) markers. This was associated with inhibition of PI3K\/AKT phosphorylation. Conversely, IL\u201017 overexpression in control VSMCs recapitulated the pathological phenotype, which was blocked by the PI3K\/AKT inhibitor Wortmannin (WM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u201017 promotes the phenotypic transformation of VSMCs in SSH through the PI3K\/AKT signaling pathway. Inhibition of IL\u201017 or the PI3K\/AKT pathway may represent a therapeutic strategy for SSH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.70050","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T15:50:03Z","timestamp":1768751403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>IL<\/scp>\n                    \u201017 Promotes the Phenotypic Transformation of Vascular Smooth Muscle Cells Through\n                    <scp>PI3K<\/scp>\n                    \/\n                    <scp>AKT<\/scp>\n                    Signaling Pathway"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4925-3372","authenticated-orcid":false,"given":"Song","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Zunyi City (The Third Affiliated Hospital of Zunyi Medical University)  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfu","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Emergency The First People's Hospital of Zunyi City (The Third Affiliated Hospital of Zunyi Medical University)  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxian","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Zunyi City (The Third Affiliated Hospital of Zunyi Medical University)  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Zunyi City (The Third Affiliated Hospital of Zunyi Medical University)  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianfeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Zunyi City (The Third Affiliated Hospital of Zunyi Medical University)  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Zunyi City (The Third Affiliated Hospital of Zunyi Medical University)  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-540X","authenticated-orcid":false,"given":"Zhenglong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Zunyi City (The Third Affiliated Hospital of Zunyi Medical University)  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Zunyi City (The Third Affiliated Hospital of Zunyi Medical University)  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First People's Hospital of Zunyi City (The Third Affiliated Hospital of Zunyi Medical University)  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuw028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-04978-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21369"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00399-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0332-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321335"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.10.006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31200"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad089"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy023"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2024.05.001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.102429"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12030"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082953"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14359"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.145094"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1256133"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.798958"},{"issue":"18","key":"e_1_2_11_20_1","first-page":"1446","article-title":"The 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