{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:03:59Z","timestamp":1785899039973,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Skin integrity is one factor determining residual limb health. Oxygen deficiency caused by energy consumption and\/or mechanical stress is the most common reason for skin breakdown at the residual limb (RL), limiting physical activity and causing residual limb pain (RLP). This study aims to detect differences in microcirculation at rest (T1) and after walking for 6\u2009min (T2) with a socket prosthesis at different zones at the residual limb (RL) and the corresponding areas at the sound limb (SL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Amputation and RLs' demographics as limb circumference (LCF), subcutaneous fat thickness (SCFT) and microcirculatory parameters as tissue oxygenation saturation (StO\n                      <jats:sub>2<\/jats:sub>\n                      ), near\u2010infrared perfusion index (NIRPI), tissue hemoglobin index (THI) and tissue water index (TWI) were visualized and analyzed at different zones of the SL and RL of ten non\u2010dysvascular major lower limb amputees at T1 and T2 using ((HIS), TIVITA Tissue Diaspective Vision, Germany).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LCF and SCFT were lower at the RL than at the SL. A significant reduction of NIRPI after walking was observed at location F2, affecting both limbs. StO\n                      <jats:sub>2<\/jats:sub>\n                      decreased significantly from T1 to T2 only at the residual limb at AL, with no corresponding change in the sound limb.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings demonstrate localized exercise\u2010related reductions in oxygenation at the distal RL, whereas microcirculation of the SL remained unchanged. Underlying factors and a possible impact on the overall residual limb health need further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.70051","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T15:43:42Z","timestamp":1768751022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hyperspectral Imaging Reveals High Water and Hemoglobin Content at Rest and Decreased Oxygen Levels After Physical Activity at the Residual Limb of Non\u2010Dysvascular Lower Limb Amputees"],"prefix":"10.1111","volume":"33","author":[{"suffix":"Jr.","given":"Luis A.","family":"Pardo","sequence":"first","affiliation":[{"name":"Hannover Medical School Department of Trauma Surgery  Hannover Germany"},{"name":"Department of Trauma Surgery, Orthopedic Surgery and Plastic Surgery University Medical Center G\u00f6ttingen  G\u00f6ttingen 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Germany"},{"name":"Department for Sport Psychology Institute for Sport Science, Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt F.","family":"Schilling","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Orthopedic Surgery and Plastic Surgery University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ernst","sequence":"additional","affiliation":[{"name":"Hannover Medical School Department of Trauma Surgery  Hannover Germany"},{"name":"Department of Trauma Surgery, Orthopedic Surgery and Plastic Surgery University Medical Center G\u00f6ttingen  G\u00f6ttingen 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