{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:16:35Z","timestamp":1791645395783,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K17652"],"award-info":[{"award-number":["21K17652"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K10942"],"award-info":[{"award-number":["23K10942"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Diabetes is associated with microvascular complications in multiple tissues. Nailfold capillaries (NFCs) provide a noninvasive window for assessing microvascular alterations; however, their temporal association with skeletal muscle microvascular changes during diabetes progression remains unclear. This study aimed to determine whether NFC structural changes reflect skeletal muscle microvascular alterations and muscle\u2010type\u2010specific vulnerability in a non\u2010obese type 2 diabetes model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Spontaneously Diabetic Torii (SDT) rats, a non\u2010obese type 2 diabetes model, and age\u2010matched Sprague\u2013Dawley rats were studied. NFC morphology was evaluated by capillaroscopy at 12, 18, and 28\u2009weeks of age. Soleus and plantaris muscles were collected for histological and gene expression analyses, and glucose tolerance was evaluated by oral glucose tolerance testing at each time point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 12\u2009weeks of age, SDT rats exhibited mild glucose intolerance without significant abnormalities in NFC morphology or skeletal muscle capillary indices. At 18\u2009weeks, when glucose intolerance became evident in the absence of persistent hyperglycemia, NFC narrowing and reduced density were observed, accompanied by capillary rarefaction in the predominantly fast\u2010twitch plantaris muscle, whereas the slow\u2010twitch soleus muscle remained relatively preserved. By 28\u2009weeks, persistent hyperglycemia was present, and overt muscle atrophy was observed exclusively in the plantaris muscle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NFC structural alterations emerge alongside skeletal muscle microvascular rarefaction at the stage of glucose intolerance and precede overt muscle atrophy in fast\u2010twitch muscle. NFC assessment may serve as a noninvasive indicator of early microvascular alterations relevant to diabetes\u2010associated skeletal muscle deterioration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.70054","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:36:37Z","timestamp":1773340597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Temporal Progression of Microvascular Alterations in the Nailfold and Skeletal Muscle of Non\u2010Obese Type 2 Diabetic Rats"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5200-4948","authenticated-orcid":false,"given":"Miho","family":"Kanazashi","sequence":"first","affiliation":[{"name":"Faculty of Health and Welfare Prefectural University of Hiroshima  Mihara 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