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While vaccines are available to protect against four <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>.\u2009meningitidis<\/jats:italic> serogroups, there is currently no commercial vaccine to protect against serogroup <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> or against <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>.\u2009gonorrhoeae<\/jats:italic>. Moreover, the available vaccines have significant limitations and with antibiotic resistance becoming an alarming issue, the search for effective vaccine targets to elicit long\u2010lasting protection against <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>eisseria<\/jats:italic> species is becoming more urgent. One strategy for vaccine development has targeted the neisserial iron import systems. Without iron, the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>eisseriae cannot survive and, therefore, these iron import systems tend to be relatively well conserved and are promising vaccine targets, having the potential to offer broad protection against both gonococcal and meningococcal infections. These efforts have been boosted by recent reports of the crystal structures of the neisserial receptor proteins <jats:styled-content style=\"fixed-case\">TbpA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TbpB<\/jats:styled-content>, each solved in complex with human transferrin, an iron binding protein normally responsible for delivering iron to human cells. Here, we review the recent structural reports and put them into perspective with available functional studies in order to derive the mechanism(s) for how the pathogenic <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>eisseriae are able to hijack human iron transport systems for their own survival and pathogenesis.<\/jats:p>","DOI":"10.1111\/mmi.12002","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T12:29:53Z","timestamp":1347020993000},"page":"246-257","source":"Crossref","is-referenced-by-count":72,"title":["The transferrin\u2013iron import system from pathogenic <i><scp>N<\/scp>eisseria<\/i> species"],"prefix":"10.1111","volume":"86","author":[{"given":"Nicholas","family":"Noinaj","sequence":"first","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health  Bethesda MD 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan 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