{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:59:16Z","timestamp":1791273556505,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:00:00Z","timestamp":1368662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Summary<\/jats:title>\n \n In\n \n C<\/jats:styled-content>\n andida glabrata\n <\/jats:italic>\n , the sirtuins\n Sir<\/jats:styled-content>\n 2 and\n Hst<\/jats:styled-content>\n 1 control the expression of a wide number of genes including adhesins required for host colonization and niacin transporters needed for growth. Given that these sirtuins can be inactivated during infection, we asked if their inhibition could modify the response of\n \n C<\/jats:styled-content>\n .\u2009glabrata\n <\/jats:italic>\n to other stressful conditions. Here, we found that deletion of\n \n HST1<\/jats:italic>\n <\/jats:styled-content>\n decreases susceptibility of\n \n C<\/jats:styled-content>\n .\u2009glabrata\n <\/jats:italic>\n to fluconazole and hydrogen peroxide. The transcription factor Pdr1 and the\n ABC<\/jats:styled-content>\n transporter\n Cdr<\/jats:styled-content>\n 1 mediated the fluconazole resistance phenotype of the\n \n hst1<\/jats:italic>\n <\/jats:styled-content>\n \u0394 cells, whereas the transcriptional activator Msn4 and the catalase\n Cta<\/jats:styled-content>\n 1 are necessary to provide oxidative stress resistance. We show that the transcription factor Sum1 interacts with Hst1 and participate in the regulation of these genes. Interestingly, even though\n \n C<\/jats:styled-content>\n .\u2009glabrata\n <\/jats:italic>\n and\n \n S<\/jats:styled-content>\n accharomyces cerevisiae\n <\/jats:italic>\n are closely related phylogenetically, deletion of\n \n HST1<\/jats:italic>\n <\/jats:styled-content>\n decreased susceptibility to fluconazole and hydrogen peroxide only in\n \n C<\/jats:styled-content>\n .\u2009glabrata\n <\/jats:italic>\n but not in\n \n S<\/jats:styled-content>\n .\u2009cerevisiae\n <\/jats:italic>\n , indicating a different transcriptional control by two similar sirtuins. Our findings suggest that\n Hst<\/jats:styled-content>\n 1 acts as a regulator of stress resistance associated\u2010genes.\n <\/jats:p>","DOI":"10.1111\/mmi.12247","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T01:18:35Z","timestamp":1368667115000},"page":"1135-1148","source":"Crossref","is-referenced-by-count":62,"title":["Local silencing controls the oxidative stress response and the multidrug resistance in\n \n C<\/scp>\n andida glabrata\n <\/i>"],"prefix":"10.1111","volume":"88","author":[{"given":"Emmanuel","family":"Orta\u2010Zavalza","sequence":"first","affiliation":[{"name":"IPICYT Divisi\u00f3n de Biolog\u00eda Molecular Instituto Potosino de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica Camino a la Presa San Jos\u00e9 2055 Lomas 4a<\/sup> secci\u00f3n San Luis Potos\u00ed 78216 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