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In this study we have identified and functionally characterized the role of sulphiredoxin,\n                    <jats:styled-content style=\"fixed-case\">Srx<\/jats:styled-content>\n                    1, in oxidative stress resistance of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      ryptococcus neoformans\n                    <\/jats:italic>\n                    causing fungal meningoencephalitis and regulation of peroxiredoxins, Tsa1 and Tsa3, and thioredoxins,\n                    <jats:styled-content style=\"fixed-case\">Trx<\/jats:styled-content>\n                    1 and\n                    <jats:styled-content style=\"fixed-case\">Trx<\/jats:styled-content>\n                    2. The\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      .\u2009neoformans\n                    <\/jats:italic>\n                    \u2005\n                    <jats:styled-content style=\"fixed-case\">HOG<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                    igh\n                    <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>\n                    smolarity\n                    <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\n                    lycerol response) pathway was essential for the transcriptional regulation of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>SRX1<\/jats:italic>\n                    <\/jats:styled-content>\n                    under peroxide stress conditions. A gene deletion study revealed that\n                    <jats:styled-content style=\"fixed-case\">Srx<\/jats:styled-content>\n                    1 was required for cells to counteract peroxide stress, but not other oxidative damaging agents.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>HOG1<\/jats:italic>\n                    <\/jats:styled-content>\n                    was found to be essential for the induction of adaptive response to peroxide stress with concurrent repression of ergosterol biosynthesis in an\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>SRX1<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>\u2010<\/jats:italic>\n                    independent manner. Consistent with this, phosphorylation of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      . neoformans\n                    <\/jats:italic>\n                    Hog1 was modulated by both low and high doses of exogenous hydrogen peroxide treatment. Immunoblot analysis using the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      .\u2009neoformans\n                    <\/jats:italic>\n                    Tsa1 specific antibody revealed that both\n                    <jats:styled-content style=\"fixed-case\">Srx<\/jats:styled-content>\n                    1 and\n                    <jats:styled-content style=\"fixed-case\">Trx<\/jats:styled-content>\n                    1 were essential for recycling of oxidized Tsa1. In addition to its role in peroxide sensing and response\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      .\u2009neoformans\n                    <\/jats:italic>\n                    \u2005\n                    <jats:styled-content style=\"fixed-case\">Srx<\/jats:styled-content>\n                    1 was also found to be required for a peroxiredoxin\u2010independent function in promoting fungicide\u2010dependent cell swelling and growth arrest. Finally we showed the importance of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      .\u2009neoformans\n                    <\/jats:italic>\n                    \u2005\n                    <jats:styled-content style=\"fixed-case\">Srx<\/jats:styled-content>\n                    1 in fungal pathogenesis by demonstrating its requirement for full virulence using a mouse infection model.\n                  <\/jats:p>","DOI":"10.1111\/mmi.12388","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T01:35:24Z","timestamp":1378172124000},"page":"630-648","source":"Crossref","is-referenced-by-count":33,"title":["Sulphiredoxin plays peroxiredoxin\u2010dependent and \u2010independent roles via the\n                    <scp>HOG<\/scp>\n                    signalling pathway in\n                    <i>\n                      <scp>C<\/scp>\n                      ryptococcus neoformans\n                    <\/i>\n                    and contributes to fungal virulence"],"prefix":"10.1111","volume":"90","author":[{"given":"Rajendra","family":"Upadhya","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology Washington University School of Medicine  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyelim","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Center for Fungal Pathogenesis College of Life Science and Biotechnology Yonsei University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang\u2010Woo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Center for Fungal Pathogenesis College of Life Science and Biotechnology Yonsei University  Seoul 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