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In fungi, many cell wall proteins are <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010anchored, and disruption of <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010anchored proteins impairs cell wall integrity. After being synthesized and attached to target proteins, <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content> anchors undergo modification on lipid moieties. In spite of its importance for <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010anchored protein functions, our current knowledge of <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content> lipid remodelling in pathogenic fungi is limited. In this study, we characterized the role of a putative <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content> lipid remodelling protein, designated <jats:styled-content style=\"fixed-case\">PerA<\/jats:styled-content>, in the human pathogenic fungus <jats:styled-content style=\"fixed-case\"><jats:italic>A<\/jats:italic><\/jats:styled-content><jats:italic>spergillus fumigatus<\/jats:italic>. <jats:styled-content style=\"fixed-case\">PerA<\/jats:styled-content> localizes to the endoplasmic reticulum and loss of <jats:styled-content style=\"fixed-case\">PerA<\/jats:styled-content> leads to striking defects in cell wall integrity. <jats:styled-content style=\"fixed-case\">A <jats:italic>perA<\/jats:italic><\/jats:styled-content> null mutant has decreased conidia production, increased susceptibility to triazole antifungal drugs, and is avirulent in a murine model of invasive pulmonary aspergillosis. Interestingly, loss of <jats:styled-content style=\"fixed-case\">PerA<\/jats:styled-content> increases exposure of \u03b2\u2010glucan and chitin content on the hyphal cell surface, but diminished <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> production by bone marrow\u2010derived macrophages relative to wild type. Given the structural specificity of fungal <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010anchors, which is different from humans, understanding <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content> lipid remodelling and <jats:styled-content style=\"fixed-case\">PerA<\/jats:styled-content> function in <jats:styled-content style=\"fixed-case\"><jats:italic>A<\/jats:italic><\/jats:styled-content><jats:italic>. fumigatus<\/jats:italic> is a promising research direction to uncover a new fungal specific antifungal drug target.<\/jats:p>","DOI":"10.1111\/mmi.12626","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T05:56:37Z","timestamp":1398837397000},"page":"1279-1298","source":"Crossref","is-referenced-by-count":21,"title":["Endoplasmic reticulum localized <scp>PerA<\/scp> is required for cell wall integrity, azole drug resistance, and virulence in <scp><i>A<\/i><\/scp><i>spergillus fumigatus<\/i>"],"prefix":"10.1111","volume":"92","author":[{"given":"Dawoon","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth  Hanover NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsa","family":"Thammahong","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth  Hanover NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Shepardson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth  Hanover NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara J.","family":"Blosser","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease Montana State University  Bozeman MT 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