{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:00Z","timestamp":1787015820423,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["097829\/Z\/11\/A"],"award-info":[{"award-number":["097829\/Z\/11\/A"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Summary<\/jats:title>\n \n \n N<\/jats:italic>\n <\/jats:styled-content>\n eisseria meningitidis<\/jats:italic>\n is an important human pathogen that is capable of killing within hours of infection. Its normal habitat is the nasopharynx of adult humans. Here we identify a genomic island (the\n \n prp<\/jats:italic>\n <\/jats:styled-content>\n gene cluster) in\n \n N<\/jats:italic>\n <\/jats:styled-content>\n . meningitidis<\/jats:italic>\n that enables this species to utilize propionic acid as a supplementary carbon source during growth, particularly under nutrient poor growth conditions. The\n \n prp<\/jats:italic>\n <\/jats:styled-content>\n gene cluster encodes enzymes for a methylcitrate cycle. Novel aspects of the methylcitrate cycle in\n \n N<\/jats:italic>\n <\/jats:styled-content>\n . meningitidis<\/jats:italic>\n include a propionate kinase which was purified and characterized, and a putative propionate transporter. This genomic island is absent from the close relative of\n \n N<\/jats:italic>\n <\/jats:styled-content>\n . meningitidis<\/jats:italic>\n , the commensal\n \n N<\/jats:italic>\n <\/jats:styled-content>\n eisseria lactamica<\/jats:italic>\n , which chiefly colonizes infants not adults. We reason that the possession of the\n \n prp<\/jats:italic>\n <\/jats:styled-content>\n genes provides a metabolic advantage to\n \n N<\/jats:italic>\n <\/jats:styled-content>\n . meningitidis<\/jats:italic>\n in the adult oral cavity, which is rich in propionic acid\u2010generating bacteria. Data from classical microbiological and sequence\u2010based microbiome studies provide several lines of supporting evidence that\n \n N<\/jats:italic>\n <\/jats:styled-content>\n . meningitidis<\/jats:italic>\n colonization is correlated with propionic acid generating bacteria, with a strong correlation between\n \n prp<\/jats:italic>\n <\/jats:styled-content>\n \u2010containing\n \n N<\/jats:italic>\n <\/jats:styled-content>\n eisseria<\/jats:italic>\n and propionic acid generating bacteria from the genus\n \n P<\/jats:italic>\n <\/jats:styled-content>\n orphyromonas<\/jats:italic>\n , and that this may explain adolescent\/adult colonization by\n \n N<\/jats:italic>\n <\/jats:styled-content>\n . meningitidis<\/jats:italic>\n .\n <\/jats:p>","DOI":"10.1111\/mmi.12664","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T07:04:58Z","timestamp":1402297498000},"page":"346-355","source":"Crossref","is-referenced-by-count":34,"title":["A large genomic island allows\n \n N<\/i>\n <\/scp>\n eisseria meningitidis<\/i>\n to utilize propionic acid, with implications for colonization of the human nasopharynx"],"prefix":"10.1111","volume":"93","author":[{"given":"Maria Chiara E.","family":"Catenazzi","sequence":"first","affiliation":[{"name":"Department of Biology University of York Heslington York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Biology University of York Heslington York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Biology University of York Heslington York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Clifton","sequence":"additional","affiliation":[{"name":"Department of Biology University of York Heslington York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P. 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