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This process is driven by a released parasite\u2010derived factor that causes parasites to accumulate in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1 and become quiescent. This is accompanied by morphological transformation to \u2018stumpy\u2019 forms that are adapted to survival and further development when taken up in the blood meal of tsetse flies, the vector for trypanosomiasis. Although the soluble signal driving differentiation to stumpy forms is unidentified, a recent genome\u2010wide <jats:styled-content style=\"fixed-case\">RNAi<\/jats:styled-content> screen identified many of the intracellular signalling and effector molecules required for the response to this signal. These resemble components of nutritional starvation and quiescence pathways in other eukaryotes, suggesting that parasite development shares similarities with the adaptive quiescence of organisms such as yeasts and <jats:styled-content style=\"fixed-case\"><jats:italic>D<\/jats:italic><\/jats:styled-content><jats:italic>ictyostelium<\/jats:italic> in response to nutritional starvation and stress. Here, the trypanosome signalling pathway is discussed in the context of these conserved pathways and the possible contributions of opposing \u2018slender retainer\u2019 and \u2018stumpy inducer\u2019 arms described. As evolutionarily highly divergent eukaryotes, the organisation and conservation of this developmental pathway can provide insight into the developmental cycle of other protozoan parasites, as well as the adaptive and programmed developmental responses of all eukaryotic cells.<\/jats:p>","DOI":"10.1111\/mmi.12949","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T07:36:42Z","timestamp":1422517002000},"page":"220-232","source":"Crossref","is-referenced-by-count":61,"title":["Assembling the components of the quorum sensing pathway in <scp>A<\/scp>frican trypanosomes"],"prefix":"10.1111","volume":"96","author":[{"given":"Binny M.","family":"Mony","sequence":"first","affiliation":[{"name":"Centre for Immunity, Infection and Evolution Institute for Immunology and Infection Research School of Biological Sciences University of Edinburgh  Charlotte Auerbach Road Edinburgh EH9\u20093FL UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith 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