{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:05:40Z","timestamp":1791018340548,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Gram\u2010positive bacteria can regulate gene expression at the population level via a mechanism known as quorum sensing. Oligopeptides serve as the signaling molecules; they are secreted and then are either detected at the bacterial surface by two\u2010component systems or reinternalized via an oligopeptide transport system. In the latter case, imported peptides interact with cognate regulators (phosphatases or transcriptional regulators) that modulate the expression of target genes. These regulators help control crucial functions such as virulence, persistence, conjugation and competence and have been reported in bacilli, enterococci and streptococci. They form the rapidly growing <jats:styled-content style=\"fixed-case\">RRNPP<\/jats:styled-content> group. In this issue of <jats:styled-content style=\"fixed-case\"><jats:italic>M<\/jats:italic><\/jats:styled-content><jats:italic>olecular<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\"><jats:italic>M<\/jats:italic><\/jats:styled-content><jats:italic>icrobiology<\/jats:italic>, Hoover <jats:italic>et\u2009al<\/jats:italic>. (2015) highlight the group's importance: they have identified a new family of regulators, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>prs (<jats:styled-content style=\"fixed-case\"><jats:bold>T<\/jats:bold><\/jats:styled-content>ranscription factor regulated by a <jats:styled-content style=\"fixed-case\"><jats:bold>P<\/jats:bold><\/jats:styled-content>h<jats:bold>r<\/jats:bold> peptide), which work with internalized <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>hr\u2010like peptides. The mechanisms underlying the expression of the genes that encode these internalized peptides are poorly documented. However, <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>oover <jats:italic>et\u2009al<\/jats:italic>. (2015) have provided a new insight: an environmental molecule, glucose, can inhibit expression of the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>hr\u2010like peptide gene via catabolic repression. This previously undescribed regulatory pathway, controlling the production of a bacteriocin, might influence <jats:italic>Streptococcus pneumonia<\/jats:italic>'s fitness in the nasopharynx, where galactose is present.<\/jats:p>","DOI":"10.1111\/mmi.13060","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T08:29:13Z","timestamp":1432024153000},"page":"181-184","source":"Crossref","is-referenced-by-count":90,"title":["Quorum\u2010sensing regulators in <scp>G<\/scp>ram\u2010positive bacteria: \u2018cherchez le peptide \u2019"],"prefix":"10.1111","volume":"97","author":[{"given":"V.","family":"Monnet","sequence":"first","affiliation":[{"name":"UMR1319 MICALIS INRA  Jouy en Josas France"},{"name":"UMR MICALIS AgroParistech  Jouy en Josas France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gardan","sequence":"additional","affiliation":[{"name":"UMR1319 MICALIS INRA  Jouy en Josas France"},{"name":"UMR MICALIS AgroParistech  Jouy en Josas France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704501104"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-111212-133449"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07633.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01251-09"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08090.x"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.02196-12"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213770110"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13029"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01057-07"},{"key":"e_1_2_2_11_1","doi-asserted-by":"crossref","first-page":"e333","DOI":"10.1128\/mBio.00333-12","article-title":"Antagonistic Rgg regulators mediate quorum sensing via competitive DNA binding in Streptococcus pyogenes","volume":"3","author":"Lasarre B.","year":"2012","journal-title":"MBio"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1438-4221(00)80024-7"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07361.x"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.55.1.165"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2014.948804"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500357112"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001516"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.2741\/913"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-010-2651-y"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins6082239"}],"container-title":["Molecular Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmmi.13060","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mmi.13060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:30:26Z","timestamp":1696239026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mmi.13060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,12]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/mmi.13060"],"URL":"https:\/\/doi.org\/10.1111\/mmi.13060","archive":["Portico"],"relation":{},"ISSN":["0950-382X","1365-2958"],"issn-type":[{"value":"0950-382X","type":"print"},{"value":"1365-2958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,12]]}}}