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In the pathogenic mucoralean fungus\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>ucor circinelloides<\/jats:italic>\n                    , calcineurin mutation or inhibition confers a yeast\u2010locked phenotype indicating that calcineurin governs the dimorphic transition. Genetic analysis in this study reveals that two calcineurin\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    catalytic subunits (out of three) are functionally diverged. Homology modeling illustrates modes of resistance resulting from amino substitutions in the interface between each calcineurin subunit and the inhibitory drugs. In addition, we show how the dimorphic transition orchestrated by calcineurin programs different outcomes during host\u2013pathogen interactions. For example, when macrophages phagocytose\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>ucor<\/jats:italic>\n                    yeast, subsequent phagosomal maturation occurs, indicating host cells respond appropriately to control the pathogen. On the other hand, upon phagocytosis of spores, macrophages fail to form mature phagosomes. Cytokine production from immune cells differs following exposure to yeast versus spores (which germinate into hyphae). Thus, the morphogenic transition can be targeted as an efficient treatment option against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>ucor<\/jats:italic>\n                    infection. In addition, genetic analysis (including gene disruption and mutational studies) further strengthens the understanding of calcineurin and provides a foundation to develop antifungal agents targeting calcineurin to deploy against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>ucor<\/jats:italic>\n                    and other pathogenic fungi.\n                  <\/jats:p>","DOI":"10.1111\/mmi.13071","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T22:56:48Z","timestamp":1432594608000},"page":"844-865","source":"Crossref","is-referenced-by-count":93,"title":["Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host\u2013pathogen interactions of the pathogenic mucoralean fungus\n                    <scp>\n                      <i>M<\/i>\n                    <\/scp>\n             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