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Comparative genome analyses revealed that the serine\u2010rich repeat (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>rr) glycoprotein Srr2 is a cell wall\u2010anchored protein specific for <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u201017 strains, the non\u2010<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u201017 isolates expressing <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>rr1. Here, we unravel the binding capacity of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> Srr proteins to relevant components of the host fibrinolysis pathway. We demonstrate that: (i) <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>rr2 binds plasminogen and plasmin whereas <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>rr1 does not; (ii) the ability of <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u201017 strains to bind fibrinogen reflects a high level surface display of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>rr2 combined with a higher affinity of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>rr2 than <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>rr1 to bind this ligand; and (iii) <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>rr2 binding to host plasma proteins results in the formation of bacterial aggregates that are efficiently endocytosed by phagocytes. Importantly, we show that <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>rr2 increased bacterial survival to phagocytic killing and bacterial persistence in a murine model of meningitis. We conclude that <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>rr2 is a multifaceted adhesin used by the <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u201017 clone to hijack ligands of the host coagulation system, thereby contributing to bacterial dissemination and invasiveness, and ultimately to meningitis.<\/jats:p>","DOI":"10.1111\/mmi.13097","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T10:34:42Z","timestamp":1434710082000},"page":"1209-1222","source":"Crossref","is-referenced-by-count":93,"title":["<scp>S<\/scp>rr2, a multifaceted adhesin expressed by <scp>ST<\/scp>\u201017 hypervirulent <scp>G<\/scp>roup <scp>B <i>S<\/i><\/scp><i>treptococcus<\/i> involved in binding to both fibrinogen and plasminogen"],"prefix":"10.1111","volume":"97","author":[{"given":"Anne","family":"Six","sequence":"first","affiliation":[{"name":"INSERM U 1016, Institut Cochin team \u2018Barriers and Pathogens\u2019  Paris F\u201075014 France"},{"name":"CNRS UMR 8104  Paris F\u201075014 France"},{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9  Paris F\u201075014 France"},{"name":"DHU \u2018Risques et grossesse\u2019 Assistance Publique H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Bellais","sequence":"additional","affiliation":[{"name":"INSERM U 1016, Institut Cochin team \u2018Barriers and Pathogens\u2019  Paris F\u201075014 France"},{"name":"CNRS UMR 8104  Paris F\u201075014 France"},{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9  Paris F\u201075014 France"},{"name":"DHU \u2018Risques et grossesse\u2019 Assistance Publique H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelouhab","family":"Bouaboud","sequence":"additional","affiliation":[{"name":"INSERM U 1016, Institut Cochin team \u2018Barriers and Pathogens\u2019  Paris F\u201075014 France"},{"name":"CNRS UMR 8104  Paris F\u201075014 France"},{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9  Paris F\u201075014 France"},{"name":"DHU \u2018Risques et grossesse\u2019 Assistance Publique H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Fouet","sequence":"additional","affiliation":[{"name":"INSERM U 1016, Institut Cochin team \u2018Barriers and Pathogens\u2019  Paris F\u201075014 France"},{"name":"CNRS UMR 8104  Paris F\u201075014 France"},{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9  Paris F\u201075014 France"},{"name":"DHU \u2018Risques et grossesse\u2019 Assistance Publique H\u00f4pitaux de Paris  Paris France"},{"name":"Centre National de R\u00e9f\u00e9rence des Streptocoques  Paris F\u201075014 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Gabriel","sequence":"additional","affiliation":[{"name":"INSERM U 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