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By the use of two extracellular nucleases and periplasmic phosphatases, <jats:styled-content style=\"fixed-case\"><jats:italic>V<\/jats:italic><\/jats:styled-content><jats:italic>.\u2009cholerae<\/jats:italic> degrades extracellular <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> to nucleosides. In this study, we investigated the nucleoside uptake via identification and characterization of VCA0179, VC1953 and VC2352 representing the three nucleoside transport systems in <jats:styled-content style=\"fixed-case\"><jats:italic>V<\/jats:italic><\/jats:styled-content><jats:italic>.\u2009cholerae<\/jats:italic>. Based on our results VC2352 seems to be the dominant nucleoside transporter. Nevertheless, all three transporters are functional and can contribute to the utilization of nucleosides as a sole source of carbon or nitrogen. We found that the transcriptional activity of these three distal genes is equally promoted or antagonized by <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CytR<\/jats:styled-content> respectively. Finally, mutants impaired for nucleoside uptake exhibit decreased transition fitness from the host into low carbon environments along the life cycle of <jats:styled-content style=\"fixed-case\"><jats:italic>V<\/jats:italic><\/jats:styled-content><jats:italic>.\u2009cholerae<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/mmi.13143","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T10:31:12Z","timestamp":1437647472000},"page":"470-483","source":"Crossref","is-referenced-by-count":22,"title":["Nucleoside uptake in <scp><i>V<\/i><\/scp><i>ibrio cholerae<\/i> and its role in the transition fitness from host to environment"],"prefix":"10.1111","volume":"99","author":[{"given":"Tanja","family":"Gumpenberger","sequence":"first","affiliation":[{"name":"Institute of Molecular Biosciences University of Graz  Humboldtstr. 50 Graz 8010 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