{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:15:01Z","timestamp":1787318101023,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"F\u00f6rderprogramm f\u00fcr Forschung und Lehre (F\u00f6FoLe) of the Medical Faculty of the Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Mitochondria within eukaryotic cells continuously fuse and divide. This phenomenon is called mitochondrial dynamics and crucial for mitochondrial function and integrity. We performed a comprehensive analysis of mitochondrial dynamics in the pathogenic mold\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>spergillus fumigatus<\/jats:italic>\n                    . Phenotypic characterization of respective mutants revealed the general essentiality of mitochondrial fusion for mitochondrial genome maintenance and the mold's viability. Surprisingly, it turned out that the mitochondrial rhomboid protease Pcp1 and its processing product, s\u2010Mgm,1 which are crucial for fusion in yeast, are dispensable for fusion, mtDNA maintenance and viability in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>. fumigatus<\/jats:italic>\n                    . In contrast, mitochondrial fission mutants show drastically reduced growth and sporulation rates and increased heat susceptibility. However, reliable inheritance of mitochondria to newly formed conidia is ensured. Strikingly, mitochondrial fission mutants show a significant and growth condition\u2010dependent increase in azole resistance. Parallel disruption of fusion in a fission mutant partially rescues growth and sporulation defects and further increases the azole resistance phenotype. Taken together, our results indicate an emerging dispensability of the mitochondrial rhomboid protease function in mitochondrial fusion, the suitability of mitochondrial fusion machinery as antifungal target and the involvement of mitochondrial dynamics in azole susceptibility.\n                  <\/jats:p>","DOI":"10.1111\/mmi.13167","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T07:24:45Z","timestamp":1439537085000},"page":"930-945","source":"Crossref","is-referenced-by-count":79,"title":["Mitochondrial dynamics in the pathogenic mold\n                    <i>\n                      <scp>A<\/scp>\n                      spergillus fumigatus\n                    <\/i>\n                    : therapeutic and evolutionary implications"],"prefix":"10.1111","volume":"98","author":[{"given":"Michael","family":"Neubauer","sequence":"first","affiliation":[{"name":"Max von Pettenkofer\u2010Institut f\u00fcr Hygiene und Medizinische Mikrobiologie 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