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Small RNAs (sRNAs) are a versatile class of regulatory molecules, and have recently been discovered to perform important tasks in the interplay between core genomic elements and horizontally\u2010acquired DNA. Together with auxiliary proteins such as the RNA\u2010chaperone Hfq and cellular ribonucleases, sRNAs typically act post\u2010transcriptionally to either promote or restrict the expression of multiple target genes. Bacterial sRNAs have been identified in core and peripheral (acquired) genome sequences, and their target suites may likewise include genes from both locations. In this review, we discuss how sRNAs influence the expression of foreign genetic material in enterobacterial pathogens, and outline the processes that foster the integration of horizontally\u2010acquired RNAs into existing regulatory networks. 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