{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:05:42Z","timestamp":1792033542065,"version":"4.4.0"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The pathogenic fungus <jats:italic>Cryptococcus neoformans<\/jats:italic> must adapt to glucose\u2010limited conditions in the lung and glucose replete conditions upon dissemination to the brain. We report that glucose controls ribosome biogenesis and translation by modulating mRNA decay through a balance of PKA and Hog1 signalling. Glucose signalling through PKA stabilized ribosomal protein (RP) mRNAs whereas glucose starvation destabilized RP transcripts through Hog1. Glucose starvation\u2010induced oxidative stress response genes, and treatment of glucose\u2010fed cells with reactive oxygen species (ROS) generating compounds repressed RP transcripts, both of which were dependent on Hog1. Stabilization of RP transcripts led to retention of polysomes in a <jats:italic>hog1<\/jats:italic>\u0394 mutant, whereas stabilization of RP transcripts by cyclic AMP did not affect translation repression, suggesting that Hog1 alone signals translation repression. In sum, this work describes a novel antagonism between PKA and Hog1 controlling ribosome biogenesis via mRNA stability in response to glucose availability in this important human pathogen.<\/jats:p>","DOI":"10.1111\/mmi.13461","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T10:14:33Z","timestamp":1467972873000},"page":"306-320","source":"Crossref","is-referenced-by-count":33,"title":["Opposing PKA and Hog1 signals control the post\u2010transcriptional response to glucose availability in <i>Cryptococcus neoformans<\/i>"],"prefix":"10.1111","volume":"102","author":[{"given":"Dithi","family":"Banerjee","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Witebsky Center for Microbial Pathogenesis and Immunology, State University of New York at Buffalo Buffalo NY 14214 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L. 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