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Sch9, a Ser\/Thr kinase of AGC family (the cAMP\u2010dependent PKA, cGMP\u2010 dependent protein kinase G and phospholipid\u2010dependent protein kinase C family), is a substrate of TOR. Here, we characterized the fungal opportunistic pathogen <jats:italic>Aspergillus fumigatus<\/jats:italic> Sch9 homologue (SchA). The <jats:italic>schA<\/jats:italic> null mutant was sensitive to rapamycin, high concentrations of calcium, hyperosmotic stress and SchA was involved in iron metabolism. The \u0394<jats:italic>schA<\/jats:italic> null mutant showed increased phosphorylation of SakA, the <jats:italic>A. fumigatus<\/jats:italic> Hog1 homologue. The <jats:italic>schA<\/jats:italic> null mutant has increased and decreased trehalose and glycerol accumulation, respectively, suggesting SchA performs different roles for glycerol and trehalose accumulation during osmotic stress. The <jats:italic>schA<\/jats:italic> was transcriptionally regulated by osmotic stress and this response was dependent on SakA and MpkC. The double <jats:italic>\u0394schA \u0394sakA<\/jats:italic> and <jats:italic>\u0394schA \u0394mpkC<\/jats:italic> mutants were more sensitive to osmotic stress than the corresponding parental strains. Transcriptomics and proteomics identified direct and indirect targets of SchA post\u2010exposure to hyperosmotic stress. Finally, \u0394<jats:italic>schA<\/jats:italic> was avirulent in a low dose murine infection model. Our results suggest there is a complex network of interactions amongst the <jats:italic>A. fumigatus<\/jats:italic> TOR, SakA and SchA pathways.<\/jats:p>","DOI":"10.1111\/mmi.13484","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T09:06:46Z","timestamp":1471597606000},"page":"642-671","source":"Crossref","is-referenced-by-count":46,"title":["The <i>Aspergillus fumigatus<\/i> SchA<sup>SCH9<\/sup> kinase modulates SakA<sup>HOG1<\/sup> MAP kinase activity and it is essential for virulence"],"prefix":"10.1111","volume":"102","author":[{"given":"Patr\u00edcia","family":"Alves de Castro","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaila Fernanda","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen K.","family":"Dolan","sequence":"additional","affiliation":[{"name":"Department of Biology Maynooth University Maynooth Co. Kildare Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Oliveira Manfiolli","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil Andrew","family":"Brown","sequence":"additional","affiliation":[{"name":"Plant Biology and Crop Science, Rothamsted Research Harpenden Herts AL5 2JQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Biology Maynooth University Maynooth Co. Kildare Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Biology Maynooth University Maynooth Co. Kildare Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego M.","family":"Ria\u00f1o\u2010Pach\u00f3n","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Nacional de Ci\u00eancia e Tecnologia do Bioetanol (CTBE), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) Caixa Postal 6192 Campinas S\u00e3o Paulo CEP 13083\u2010970 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio M\u00e1rcio","family":"Squina","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Nacional de Ci\u00eancia e Tecnologia do Bioetanol (CTBE), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) Caixa Postal 6192 Campinas S\u00e3o Paulo CEP 13083\u2010970 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Caldana","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Nacional de Ci\u00eancia e Tecnologia do Bioetanol (CTBE), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) Caixa Postal 6192 Campinas S\u00e3o Paulo CEP 13083\u2010970 Brasil"},{"name":"Max Planck Partner Group at Brazilian Bioethanol Science and Technology Laboratory Brazilian Center for Research in Energy and Materials, S\u00e3o Paulo  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Del Poeta","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center, Chiba University Chiba 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