{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T22:08:10Z","timestamp":1789855690148,"version":"4.0.1"},"reference-count":69,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Group A Streptococcus (GAS), or <jats:italic>Streptococcus pyogenes<\/jats:italic>, is a human pathogen that causes diseases ranging from skin and soft tissue infections to severe invasive diseases, such as toxic shock syndrome. Each GAS strain carries a particular pilus type encoded in the variable <jats:bold>f<\/jats:bold>ibronectin\u2010binding, <jats:bold>c<\/jats:bold>ollagen\u2010binding, <jats:bold>T<\/jats:bold> antigen (FCT) genomic region. Here, we describe the functional analysis of the serotype M2 pilus encoded in the FCT\u20106 region. We found that, in contrast to other investigated GAS pili, the ancillary pilin 1 lacks adhesive properties. Instead, the backbone pilin is important for host cell adhesion and binds several host factors, including fibronectin and fibrinogen. Using a panel of recombinant pilus proteins, GAS gene deletion mutants and <jats:italic>Lactococcus lactis<\/jats:italic> gain\u2010of\u2010function mutants we show that, unlike other GAS pili, the FCT\u20106 pilus also contributes to immune evasion. This was demonstrated by a delay in blood clotting, increased intracellular survival of the bacteria in macrophages, higher bacterial survival rates in human whole blood and greater virulence in a <jats:italic>Galleria mellonella<\/jats:italic> infection model in the presence of fully assembled FCT\u20106 pili.<\/jats:p>","DOI":"10.1111\/mmi.13556","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T23:03:15Z","timestamp":1476486195000},"page":"282-298","source":"Crossref","is-referenced-by-count":37,"title":["The Group A Streptococcus serotype <scp>M<\/scp>2 pilus plays a role in host cell adhesion and immune evasion"],"prefix":"10.1111","volume":"103","author":[{"given":"Jia\u2010Yun C.","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine &amp; Pathology, School of Medical Sciences"},{"name":"Maurice Wilkins Centre, The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacelyn M. 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