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These distinct harmful and beneficial roles of H<jats:sub>2<\/jats:sub>S suggest the need to \u2018sense\u2019 prevailing concentrations of sulfide and downstream reactive sulfur species (RSS) and regulate the expression of genes mediating sulfide homeostasis. The paper by Li <jats:italic>et al<\/jats:italic>. in this issue of <jats:italic>Molecular Microbiology<\/jats:italic> adds <jats:italic>Cupriavidus<\/jats:italic> FisR to an expanding repertoire of regulatory mechanisms that bacteria have evolved to sense cellular RSS and mitigate their deleterious effects.<\/jats:p>","DOI":"10.1111\/mmi.13726","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T08:24:50Z","timestamp":1497428690000},"page":"347-352","source":"Crossref","is-referenced-by-count":17,"title":["A new player in bacterial sulfide\u2010inducible transcriptional regulation"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-1620","authenticated-orcid":false,"given":"David P.","family":"Giedroc","sequence":"first","affiliation":[{"name":"Department of Chemistry Indiana University Bloomington IN 47405\u20107102 USA"},{"name":"Department of Molecular and Cellular Biochemistry Indiana University Bloomington 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