{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:44:54Z","timestamp":1790952294080,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["13\/CDA\/2142"],"award-info":[{"award-number":["13\/CDA\/2142"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["12\/RI\/2346(3)"],"award-info":[{"award-number":["12\/RI\/2346(3)"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    , a ubiquitous human fungal pathogen, produces asexual spores (conidia), which are the main mode of propagation, survival and infection of this human pathogen. In this study, we present the molecular characterization of a novel regulator of conidiogenesis and conidial survival called MybA because the predicted protein contains a Myb DNA binding motif. Cellular localization of the MybA::Gfp fusion and immunoprecipitation of the MybA::Gfp or MybA::3xHa protein showed that MybA is localized to the nucleus. RNA sequencing data and a\n                    <jats:italic>uidA<\/jats:italic>\n                    reporter assay indicated that the MybA protein functions upstream of\n                    <jats:italic>wetA<\/jats:italic>\n                    ,\n                    <jats:italic>vosA<\/jats:italic>\n                    and\n                    <jats:italic>velB<\/jats:italic>\n                    , the key regulators involved in conidial maturation. The deletion of\n                    <jats:italic>mybA<\/jats:italic>\n                    resulted in a very significant reduction in the number and viability of conidia. As a consequence, the \u0394\n                    <jats:italic>mybA<\/jats:italic>\n                    strain has a reduced virulence in an experimental murine model of aspergillosis. RNA\u2010sequencing and biochemical studies of the \u0394\n                    <jats:italic>mybA<\/jats:italic>\n                    strain suggested that MybA protein controls the expression of enzymes involved in trehalose biosynthesis as well as other cell wall and membrane\u2010associated proteins and ROS scavenging enzymes. In summary, MybA protein is a new key regulator of conidiogenesis and conidial maturation and survival, and plays a crucial role in propagation and virulence of\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/mmi.13744","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T03:06:42Z","timestamp":1499224002000},"page":"880-900","source":"Crossref","is-referenced-by-count":40,"title":["MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen\n                    <i>Aspergillus fumigatus<\/i>"],"prefix":"10.1111","volume":"105","author":[{"given":"Isabel","family":"Valsecchi","sequence":"first","affiliation":[{"name":"Unit\u00e9 des Aspergillus Institut Pasteur Paris 75015 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Sarikaya\u2010Bayram","sequence":"additional","affiliation":[{"name":"Department of Biology Maynooth University Maynooth Co. 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