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For the most part, the utility of these compounds has been as laboratory tools for the study of EF\u2010Tu and the ribosome, as their poor pharmacokinetic profile and solubility has prevented implementation as therapeutic agents. However, due to the slowing of the antibiotic pipeline and the rapid emergence of resistance to approved antibiotics, this group is being reconsidered. Some researchers are using screens for novel naturally produced variants, while others are making directed, systematic chemical improvements on publically disclosed compounds. As an example of the latter approach, a GE2270 A derivative, LFF571, has completed phase 2 clinical trials, thus demonstrating the potential for elfamycins to become more prominent antibiotics in the future.<\/jats:p>","DOI":"10.1111\/mmi.13750","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T12:12:40Z","timestamp":1500120760000},"page":"22-34","source":"Crossref","is-referenced-by-count":73,"title":["Elfamycins: inhibitors of elongation factor\u2010Tu"],"prefix":"10.1111","volume":"106","author":[{"given":"Samantha M.","family":"Prezioso","sequence":"first","affiliation":[{"name":"Microbiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences Emory University School of Medicine Atlanta GA 30322 USA"},{"name":"Division of Pulmonology, Allergy\/Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics Emory University School of Medicine Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole E.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Emory University School of Medicine Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-5188","authenticated-orcid":false,"given":"Joanna B.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Allergy\/Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics Emory University School of Medicine Atlanta GA 30322 USA"},{"name":"Emory+Children's Center for Cystic Fibrosis and Airway Disease Research, Emory University School of Medicine Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,9]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00937-6"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(96)00123-2"},{"key":"e_1_2_15_4_1","unstructured":"ACD\/Chemsketch version 12.01 Advanced Chemistry Development Inc. 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