{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:08:59Z","timestamp":1791497339747,"version":"4.3.4"},"reference-count":117,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH NIAID","award":["R21 AI114277"],"award-info":[{"award-number":["R21 AI114277"]}]},{"name":"Department of Defense, Air Force office of Scientific Research, National Defense Science and Engineering Graduate Fellowship","award":["32 CFR 168a"],"award-info":[{"award-number":["32 CFR 168a"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Emerging lipidomic technologies have enabled researchers to dissect the complex roles of phospholipases in lipid metabolism, cellular signaling and immune regulation. Host phospholipase products are involved in stimulating and resolving the inflammatory response to pathogens. While many pathogen\u2010derived phospholipases also manipulate the immune response, they have recently been shown to be involved in lipid remodeling and scavenging during replication. Animal and plant hosts as well as many pathogens contain a family of patatin\u2010like phospholipases, which have been shown to have\u00a0phospholipase A<jats:sub>2<\/jats:sub> activity. Proteins containing patatin\u2010like phospholipase domains have been identified in protozoan parasites within the Apicomplexa phylum. These parasites are the causative agents of some of the most widespread human diseases. Malaria, caused by <jats:italic>Plasmodium<\/jats:italic> spp., kills nearly half a million people worldwide each year. <jats:italic>Toxoplasma<\/jats:italic> and <jats:italic>Cryptosporidium<\/jats:italic> infect millions of people each year with lethal consequences in immunocompromised populations. Parasite\u2010derived patatin\u2010like phospholipases are likely effective drug targets and progress in the tools available to the Apicomplexan field will allow for a closer look at the interplay of lipid metabolism and immune regulation during host infection.<\/jats:p>","DOI":"10.1111\/mmi.13871","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T11:32:36Z","timestamp":1509535956000},"page":"34-46","source":"Crossref","is-referenced-by-count":50,"title":["Patatin\u2010like phospholipases in microbial infections with emerging roles in fatty acid metabolism and immune regulation by Apicomplexa"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-248X","authenticated-orcid":false,"given":"Sarah K.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology University of Wisconsin\u2010Madison Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-8088","authenticated-orcid":false,"given":"Laura J.","family":"Knoll","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology University of Wisconsin\u2010Madison Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07904.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.02402-14"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302577200"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507261200"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26957-0"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.11.004"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105193200"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411465200"},{"key":"e_1_2_3_10_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/978-3-540-29805-2_976","article-title":"Cyclooxygenases in biology and disease","volume":"12","author":"Botting R.M.","year":"2007","journal-title":"Encycl Pain"},{"key":"e_1_2_3_11_1","first-page":"1","article-title":"Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR\/CAS9 efficient gene disruption in diverse","volume":"5","author":"Brown K.M.","year":"2014","journal-title":"mBio"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R900004-JLR200"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004760"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800033-JLR200"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2005.02578.x"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-22-4-0469"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3483"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00101-6"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(99)00186-3"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.15.3049"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001904"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00647.x"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-423525"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01431-06"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.05.008"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.2000.00802.x"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M048553"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3360659"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2001000500002"},{"key":"e_1_2_3_30_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/B978-012473345-9\/50009-X","article-title":"Lipid and membrane metabolism of the malaria parasite and the African trypanosome","volume":"8","author":"Fish W.R.","year":"1995","journal-title":"Mol Biochem Parasitol"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701893104"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.17.10733"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-001-0525-z"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501523200"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181455"},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.139"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2008.08.005"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2740121"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.768176"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb06198.x"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.01.06.db05-0982"},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800082-JLR200"},{"key":"e_1_2_3_43_1","doi-asserted-by":"crossref","first-page":"35732","DOI":"10.1038\/srep35732","article-title":"SREBP\u20102\/PNPLA8 axis improves non\u2010alcoholic fatty liver disease through activation of autophagy","volume":"6","author":"Kim K.\u2010Y.","year":"2016","journal-title":"Sci Rep"},{"key":"e_1_2_3_44_1","first-page":"73","article-title":"Evidence for pharmacologically active prostaglandins in yeasts","volume":"87","author":"Kock J.","year":"1991","journal-title":"S Afr J Sci"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.09.011"},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00322-0"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2003.07.003"},{"key":"e_1_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90581-9"},{"key":"e_1_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003082"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115678"},{"key":"e_1_2_3_51_1","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1128\/iai.65.10.4152-4157.1997","article-title":"Enhancement of neutrophil\u2010mediated killing of Plasmodium falciparum asexual blood forms by fatty acids: Importance of fatty acid structure","volume":"65","author":"Kumaratilake L.M.","year":"1997","journal-title":"Infect Immun"},{"key":"e_1_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2010.01555.x"},{"key":"e_1_2_3_53_1","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1016\/S0021-9258(17)33050-8","article-title":"Kinetic analysis of the action of soybean lipoxygenase linoleic acid","volume":"251","author":"Lagocki J.W.","year":"1976","journal-title":"J Biol Chem"},{"key":"e_1_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500290-JLR200"},{"key":"e_1_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.062405.154007"},{"key":"e_1_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01184-06"},{"key":"e_1_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13694"},{"key":"e_1_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.07.007"},{"key":"e_1_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2095-3119(16)61437-5"},{"key":"e_1_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.3.1284-1290.2004"},{"key":"e_1_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176700"},{"key":"e_1_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(03)00070-4"},{"key":"e_1_2_3_63_1","unstructured":"Mitschler R.R.(1994)Lipid biology ofCryptosporidium parvumandEimeria nieschulzi(Apicomplexa). (Doctoral Thesis)Kansas State University Kansas USA."},{"key":"e_1_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1994.tb05927.x"},{"key":"e_1_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05538.x"},{"key":"e_1_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400832101"},{"key":"e_1_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064950"},{"key":"e_1_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2015"},{"key":"e_1_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)90775-I"},{"key":"e_1_2_3_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006362"},{"key":"e_1_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709956200"},{"key":"e_1_2_3_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200189109"},{"key":"e_1_2_3_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1404372111"},{"key":"e_1_2_3_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.3.517-533.2003"},{"key":"e_1_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-007-0871-6"},{"key":"e_1_2_3_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2012.08.005"},{"key":"e_1_2_3_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2015.07.005"},{"key":"e_1_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302472200"},{"key":"e_1_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-003-0831-8"},{"key":"e_1_2_3_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24402"},{"key":"e_1_2_3_81_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104901"},{"key":"e_1_2_3_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00155-10"},{"key":"e_1_2_3_83_1","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1074\/jbc.M109.076331","article-title":"Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae","volume":"285","author":"Rajakumari S.","year":"2010","journal-title":"J Biol Chem"},{"key":"e_1_2_3_84_1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.plipres.2013.06.003","article-title":"Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans","volume":"52","author":"Ramakrishnana S.","year":"2013","journal-title":"Prog Lipid Res"},{"key":"e_1_2_3_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00234-1"},{"key":"e_1_2_3_86_1","first-page":"259","article-title":"Effect of choline kinase inhibitor hexadecyltrimethylammonium bromide on Plasmodium falciparum gene expression","volume":"45","author":"Ridzuan M.","year":"2014","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_3_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2008.00791.x"},{"key":"e_1_2_3_88_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800042-JLR200"},{"key":"e_1_2_3_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2013.06.006"},{"key":"e_1_2_3_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2004.03.004"},{"key":"e_1_2_3_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1991.tb04816.x"},{"key":"e_1_2_3_92_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4269\/ajtmh.1989.40.145","article-title":"The role of phospholipase in host cell penetration by Toxoplasma gondii","volume":"40","author":"Saffer L.D.","year":"1989","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_3_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00140-3"},{"key":"e_1_2_3_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2820055"},{"key":"e_1_2_3_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04194.x"},{"key":"e_1_2_3_96_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/toxins8110307","article-title":"Pseudomonas aeruginosa Type III secretory toxin ExoU and its predicted homologs","volume":"8","author":"Sawa T.","year":"2016","journal-title":"Toxins"},{"key":"e_1_2_3_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2010.09.005"},{"key":"e_1_2_3_98_1","doi-asserted-by":"crossref","first-page":"C055673","DOI":"10.1194\/jlr.C055673","article-title":"Lipolysis meets inflammation \u2013arachidonic acid mobilization from fat","volume":"55","author":"Schreiber R.","year":"2014","journal-title":"J Lip Res"},{"key":"e_1_2_3_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2008.07.004"},{"key":"e_1_2_3_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.pcp.a028952"},{"key":"e_1_2_3_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13479"},{"key":"e_1_2_3_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mcg084"},{"key":"e_1_2_3_103_1","first-page":"6307","article-title":"Lipoxygenase modulation to reverse carcinogenesis","volume":"61","author":"Shureiqi I.","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_3_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100450"},{"key":"e_1_2_3_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00105-0"},{"key":"e_1_2_3_106_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00131a022"},{"key":"e_1_2_3_107_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.8.4247-4253.2002"},{"key":"e_1_2_3_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2013.08.006"},{"key":"e_1_2_3_109_1","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1128\/iai.61.4.1432-1441.1993","article-title":"Eicosanoid production by mouse peritoneal macrophages during Toxoplasma gondii penetration: Role of parasite and host cell phospholipases","volume":"61","author":"Thardin J.F.","year":"1993","journal-title":"Infect Immun"},{"key":"e_1_2_3_110_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05543-11"},{"key":"e_1_2_3_111_1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1128\/IAI.00444-13","article-title":"A Toxoplasma patatin\u2010like protein changes localization and alters the cytokine response during Toxoplasmic encephalitis","volume":"82","author":"Tobin C.M.","year":"2014","journal-title":"Infect Immun"},{"key":"e_1_2_3_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307308101"},{"key":"e_1_2_3_113_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403855200"},{"key":"e_1_2_3_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2809"},{"key":"e_1_2_3_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00107-4"},{"key":"e_1_2_3_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12157"},{"key":"e_1_2_3_117_1","doi-asserted-by":"publisher","DOI":"10.2307\/3283384"},{"key":"e_1_2_3_118_1","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1242\/jeb.204.23.4157","article-title":"A snake venom phospholipase A2 blocks malaria parasite development in the mosquito midgut by inhibiting ookinete association with the midgut surface","volume":"204","author":"Zieler H.","year":"2001","journal-title":"J Exp Biol"}],"container-title":["Molecular Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmmi.13871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mmi.13871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T15:21:36Z","timestamp":1694877696000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mmi.13871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,23]]},"references-count":117,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/mmi.13871"],"URL":"https:\/\/doi.org\/10.1111\/mmi.13871","archive":["Portico"],"relation":{},"ISSN":["0950-382X","1365-2958"],"issn-type":[{"value":"0950-382X","type":"print"},{"value":"1365-2958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,23]]}}}