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The intracellular parasite <jats:italic>Toxoplasma gondii<\/jats:italic> possesses three distinct Drps. TgDrpC, whose function remains unresolved, is unusual in that it lacks a conserved GTPase Effector Domain, which is typically required for function. Here, we show that TgDrpC localizes to cytoplasmic puncta; however, in dividing parasites, TgDrpC redistributes to the growing edge of the daughter cells. By conditional knockdown, we determined that loss of TgDrpC stalls division and leads to rapid deterioration of multiple organelles and the IMC. We also show that TgDrpC interacts with proteins that exhibit homology to those involved in vesicle transport, including members of the adaptor complex 2. Two of these proteins, a homolog of the adaptor protein 2 (AP\u20102) complex subunit alpha\u20101 and a homolog of the ezrin\u2013radixin\u2013moesin (ERM) family proteins, localize to puncta and associate with the daughter cells. Consistent with the association with vesicle transport proteins, re\u2010distribution of TgDrpC to the IMC during division is dependent on post\u2010Golgi trafficking. Together, these results support that TgDrpC contributes to vesicle trafficking and is critical for stability of parasite organelles and division.<\/jats:p>","DOI":"10.1111\/mmi.14138","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T09:03:54Z","timestamp":1540544634000},"page":"46-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["TgDrpC, an atypical dynamin\u2010related protein in <i>Toxoplasma gondii, <\/i>is associated with vesicular transport factors and parasite division"],"prefix":"10.1111","volume":"111","author":[{"given":"Irene","family":"Heredero\u2010Bermejo","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Indiana University School of Medicine Indianapolis IN 46202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Varberg","sequence":"additional","affiliation":[{"name":"Department of 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