{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:44:37Z","timestamp":1747187077507,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32 GM119311","R01 GM106239"],"award-info":[{"award-number":["F32 GM119311","R01 GM106239"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The general stress response (GSR) allows many bacterial species to react to myriad different stressors. In <jats:italic>Alphaproteobacteria<\/jats:italic>, this signaling pathway proceeds through the partner\u2010switching PhyR\u2010EcfG sigma\u2010factor mechanism and is involved in multiple life processes, including virulence in <jats:italic>Brucella abortus<\/jats:italic>. To date, details of the alphaproteobacterial GSR signaling pathway have been determined using genetic and biochemical work on a diverse set of species distributed throughout the clade. Fiebig and co\u2010workers establish <jats:italic>Erythrobacter litoralis<\/jats:italic> DSM 8509 as a genetically tractable lab strain and use it to both directly and indirectly delineate photoresponsive GSR pathways mediated by multiple HWE\/HisKA_2 histidine kinases. The existence of a new phototrophic lab strain allows researchers to compare the GSR across different <jats:italic>Alphaproteobacteria<\/jats:italic>, as well as study the interplay between the GSR and phototrophy. Additionally, the discovery of new HWE\/HisKA_2 kinases regulating the GSR poses new questions about how different stimuli feed into this widespread stress pathway.<\/jats:p>","DOI":"10.1111\/mmi.14311","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T17:36:03Z","timestamp":1558632963000},"page":"438-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shining light on the alphaproteobacterial general stress response"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-7788","authenticated-orcid":false,"given":"Igor","family":"Dikiy","sequence":"first","affiliation":[{"name":"Structural Biology Initiative CUNY Advanced Science Research Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-2556","authenticated-orcid":false,"given":"Kevin 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