{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:44Z","timestamp":1787015864768,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Gram\u2010positive bacterium\n                    <jats:italic>Streptococcus pneumoniae,<\/jats:italic>\n                    the pneumococcus, is an important commensal resident of the human nasopharynx. Carriage is usually asymptomatic, however,\n                    <jats:italic>S. pneumoniae<\/jats:italic>\n                    can become invasive and spread from the upper respiratory tract to the lungs causing pneumonia, and to other organs to cause severe diseases such as bacteremia and meningitis. Several pneumococcal proteins important for its disease\u2010causing capability have been described and many are expressed on the bacterial surface. The surface located pneumococcal type\u20101 pilus has been associated with virulence and the inflammatory response, and it is present in 20%\u201330% of clinical isolates. Its tip protein RrgA has been shown to be a major adhesin to human cells and to promote invasion through the blood\u2010brain barrier. In this review we discuss recent findings of the impact of RrgA on bacterial colonization of the upper respiratory tract and on pneumococcal virulence, and use epidemiological data and genome\u2010mining to suggest trade\u2010off mechanisms potentially explaining the rather low prevalence of pilus\u20101 expressing pneumococci in humans.\n                  <\/jats:p>","DOI":"10.1111\/mmi.14451","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T07:48:30Z","timestamp":1584517710000},"page":"650-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The impact of the ancillary pilus\u20101 protein RrgA of\n                    <i>Streptococcus pneumoniae<\/i>\n                    on colonization and disease"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-9120","authenticated-orcid":false,"given":"Federico","family":"Iovino","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Nannapaneni","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5429-4759","authenticated-orcid":false,"given":"Birgitta","family":"Henriques\u2010Normark","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden"},{"name":"Department of Clinical Microbiology Karolinska University Hospital Stockholm Sweden"},{"name":"Singapore Centre on Environmental Life Sciences Engineering (SCELSE) and Lee Kong Chian School of Medicine (LKC) Nanyang Technological University (NTU) Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Normark","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden"},{"name":"Singapore Centre on Environmental Life Sciences Engineering (SCELSE) and Lee Kong Chian School of Medicine (LKC) Nanyang Technological University (NTU) Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.01.013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv461"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.12.005"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511017103"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05117-11"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.398875"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b07247"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b02587"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119172109"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080814"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/374624"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030168"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1987-z"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2895"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evu120"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17850-9"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021269"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522946113"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.10.076"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06396.x"},{"issue":"3","key":"e_1_2_5_22_1","first-page":"39S","article-title":"Streptococcus pneumoniae and community\u2010acquired pneumonia: A cause for concern","volume":"117","author":"File T. 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