{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:18Z","timestamp":1787015778484,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91951202"],"award-info":[{"award-number":["91951202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    PAO1, an opportunistic human pathogen, deploys several strategies to resist antibiotics. It uses multidrug efflux pumps, including the MexAB\u2010OprM pump, for antibiotic resistance, and it also produces hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) that provides some defense against antibiotics. MexR functions as a transcriptional repressor of the\n                    <jats:italic>mexAB\u2010oprM<\/jats:italic>\n                    operon. MexR responds to oxidative stresses caused by antibiotic exposure, and it also displays a growth phase\u2010dependent derepression of the\n                    <jats:italic>mexAB\u2010oprM<\/jats:italic>\n                    operon. However, the intrinsic inducer has not been identified. Here, we report that\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    PAO1 produced sulfane sulfur, including glutathione persulfide and inorganic polysulfide, produced from either H\n                    <jats:sub>2<\/jats:sub>\n                    S oxidation or from L\u2010cysteine metabolism. Sulfane sulfur directly reacted with MexR, forming di\u2010 and trisulfide cross\u2010links between two Cys residues, to derepress the\n                    <jats:italic>mexAB\u2010oprM<\/jats:italic>\n                    operon. Levels of cellular sulfane sulfur and\n                    <jats:italic>mexAB\u2010oprM<\/jats:italic>\n                    expression varied during growth, and both reached the maximum during the stationary phase of growth. Thus, self\u2010produced H\n                    <jats:sub>2<\/jats:sub>\n                    S and sulfane sulfur may facilitate antibiotic resistance via inducing the expression of antibiotic resistance genes.\n                  <\/jats:p>","DOI":"10.1111\/mmi.14593","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T22:35:22Z","timestamp":1598999722000},"page":"1038-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Sulfane Sulfur is an intrinsic signal activating MexR\u2010regulated antibiotic resistance in\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1111","volume":"114","author":[{"given":"Guanhua","family":"Xuan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjuan","family":"L\u00fc","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangwei","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-5318","authenticated-orcid":false,"given":"Huaiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhen","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University Qingdao People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-9016","authenticated-orcid":false,"given":"Luying","family":"Xun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University Qingdao People's Republic of China"},{"name":"School of Molecular Biosciences Washington State University Pullman WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01311-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.059"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.07.016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2011.04.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803391105"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2010.96"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio820"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2014.02.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.3.807-812.2001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2011.01.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0021-9258(18)60371-0","article-title":"Microbial 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