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The changes in environment from human to mosquito activate gametogenesis, including a drop in temperature, a rise in pH, and a mosquito\u2010derived molecule, xanthurenic acid. Signaling receptors have not been identified in malaria parasites but mounting evidence indicates that cGMP homeostasis is key to sensing extracellular cues in gametocytes. Low levels of cGMP maintained by phosphodiesterases prevent precocious activation of gametocytes in the human blood. Upon ingestion, initiation of gametogenesis depends on the activation of a hybrid guanylyl cyclase\/P4\u2010ATPase. Elevated cGMP levels lead to the rapid mobilization of intracellular calcium that relies upon the activation of both cGMP\u2010dependent protein kinase and phosphoinositide phospholipase C. Once calcium is released, a cascade of phosphorylation events mediated by calcium\u2010dependent protein kinases and phosphatases regulates the cellular processes required for gamete formation. cGMP signaling also triggers timely egress from the host cell at other life cycle stages of malaria parasites and in <jats:italic>Toxoplasma gondii<\/jats:italic>, a related apicomplexan parasite. This suggests that cGMP signaling is a versatile platform transducing external cues into calcium signals at important decision points in the life cycle of apicomplexan parasites.<\/jats:p>","DOI":"10.1111\/mmi.14633","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T15:09:04Z","timestamp":1603897744000},"page":"829-838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["cGMP homeostasis in malaria parasites\u2014The key to perceiving and integrating environmental changes during transmission to the mosquito"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3911-5537","authenticated-orcid":false,"given":"Mathieu","family":"Brochet","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Medicine, Faculty of Medicine University of Geneva Geneva 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