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The complex life cycle of\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasites is shared between two hosts, with infection of multiple cell types, and the parasite needs to adapt for survival and transmission through significantly different metabolic environments. Within the blood\u2010stage alone, parasites encounter changing levels of key nutrients, including sugars, amino acids, and lipids, due to differences in host dietary nutrition, cellular tropism, and pathogenesis. In this review, we consider the mechanisms that the most lethal of malaria parasites,\n                    <jats:italic>Plasmodium falciparum,<\/jats:italic>\n                    uses to sense nutrient levels and elicit changes in gene expression during blood\u2010stage infections. These changes are brought about by several metabolic intermediates and their corresponding sensor proteins. Sensing of distinct nutritional signals can drive\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    to alter the key blood\u2010stage processes of proliferation, antigenic variation, and transmission.\n                  <\/jats:p>","DOI":"10.1111\/mmi.14652","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T05:10:33Z","timestamp":1606281033000},"page":"891-900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Linking nutrient sensing and gene expression in\n                    <i>Plasmodium falciparum<\/i>\n                    blood\u2010stage parasites"],"prefix":"10.1111","volume":"115","author":[{"given":"Manish","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases Harvard T. H. 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