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Distinct environmental cues lead to activation of gliding motility and have become a prominent focus of recent investigation. Progress has been made toward understanding what environmental cues are sensed and how these signals are transduced in order to regulate the machinery and cellular events powering gliding motility. In this review, we will discuss new findings and integrate these into our current understanding to propose a model of how environmental sensing is achieved to regulate gliding motility in <jats:italic>Toxoplasma<\/jats:italic>. Collectively, these findings also have implications for the understanding of gliding motility across Apicomplexa more broadly.<\/jats:p>","DOI":"10.1111\/mmi.14661","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T16:46:31Z","timestamp":1607186791000},"page":"916-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Environmental sensing and regulation of motility in <i>Toxoplasma<\/i>"],"prefix":"10.1111","volume":"115","author":[{"given":"Alessandro D.","family":"Uboldi","sequence":"first","affiliation":[{"name":"Division of Infectious Disease and Immune Defense The Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia"},{"name":"The Department of Medical Biology The University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Louise","family":"Wilde","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Immune Defense The Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia"},{"name":"The Department of Medical Biology The University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-9833","authenticated-orcid":false,"given":"Stefanie M.","family":"Bader","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Immune Defense The Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7036-6222","authenticated-orcid":false,"given":"Christopher J.","family":"Tonkin","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Immune Defense The Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia"},{"name":"The Department of Medical Biology The University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170213"},{"key":"e_1_2_5_3_1","article-title":"A multipass membrane protein interacts with the cGMP\u2010dependent protein kinase to regulate critical calcium signals in malaria parasites","author":"Balestra A.C.","year":"2020","journal-title":"BioRxiv"},{"issue":"752","key":"e_1_2_5_4_1","first-page":"e759","article-title":"A comprehensive subcellular atlas of the Toxoplasma proteome via hyperLOPIT provides spatial context for protein functions","volume":"28","author":"Barylyuk K.","year":"2020","journal-title":"Cell Host & Microbe"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.10.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.05.017"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0339-8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.813972"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.652511"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.01.039"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001806"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","unstructured":"Brown K.M. 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