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To survive and reproduce, <jats:italic>Wolbachia<\/jats:italic> interacts with and modifies host subcellular structures, while sensing and responding to changes within the cellular environment. In mutualistic associations, <jats:italic>Wolbachia<\/jats:italic> may provision the host with metabolites, or help to maintain the chemical homeostasis of the host cell. Some strains can rapidly invade insect populations by manipulating host reproductive biology, while also preventing viral replication, allowing their use in vector control of arthropod\u2010borne viruses. The <jats:italic>Aedes albopictu<\/jats:italic>s\u2010derived strain <jats:italic>w<\/jats:italic>AlbB is promising in this regard. When transinfected into the Yellow fever mosquito, <jats:italic>Aedes aegypti<\/jats:italic>, <jats:italic>w<\/jats:italic>AlbB reaches high frequencies within wild populations, and strongly inhibits viral transmission. Despite its obvious potential, much is still unknown about the molecular interactions between <jats:italic>Wolbachia<\/jats:italic> and host that enable its use in vector control. Furthermore, most <jats:italic>Wolbachia<\/jats:italic> transinfection research to date has focused on host effects. In the current study, we used a cell line model to explore the effect of transinfection of <jats:italic>w<\/jats:italic>AlbB from <jats:italic>Ae<\/jats:italic>. <jats:italic>albopictus<\/jats:italic> to <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic>. Using RNA sequencing, we show that several genes associated with host\u2010symbiont interactions were downregulated by transinfection, with the greatest downregulation exhibited by prophage\u2010associated genes.<\/jats:p>","DOI":"10.1111\/mmi.14668","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T19:52:14Z","timestamp":1608148334000},"page":"1229-1243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Altered gene expression profile of <i>Wolbachia pipientis w<\/i>AlbB strain following transinfection from its native host <i>Aedes albopictus<\/i> to <i>Aedes aegypti<\/i> cells"],"prefix":"10.1111","volume":"115","author":[{"given":"Cameron","family":"Bishop","sequence":"first","affiliation":[{"name":"Australian Infectious Disease Research Centre School of Biological Sciences The University of Queensland Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7885-6544","authenticated-orcid":false,"given":"Sassan","family":"Asgari","sequence":"additional","affiliation":[{"name":"Australian Infectious Disease Research Centre School of Biological Sciences The University of Queensland Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00425-08"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25545-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00432-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2013.07.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000833"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001361"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13155"},{"volume-title":"Phage\u2010mediated manipulation of Wolbachia","year":"2019","author":"Bordenstein S.R.","key":"e_1_2_7_11_1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340170405"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019757"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-7-68"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000368"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-013-0339-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0668-x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022703"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191530"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1049"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00048-16"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00292721"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/160.3.1087"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50264-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-020-01662-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-014-9758-x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01456"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008410"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013398"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.213.1"},{"key":"e_1_2_7_31_1","first-page":"247","article-title":"Preliminary results on the effect of tetracycline on the embryogenesis and symbiotic bacteria (Wolbachia) of Dirofilaria immitis. 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