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To achieve this goal, these single\u2010celled eukaryotes export a series of effector proteins from organelles known as \u201cdense granules\u201d that interfere with normal cellular processes and responses to invasion. While some effectors are found attached to the outer surface of the parasitophorous vacuole (PV) in which\n                    <jats:italic>Toxoplasma<\/jats:italic>\n                    tachyzoites reside, others are found in the host cell's cytoplasm and yet others make their way into the host nucleus, where they alter host transcription. Among the processes that are severely altered are innate immune responses, host cell cycle, and association with host organelles. The ways in which these crucial processes are altered through the coordinated action of a large collection of effectors is as elegant as it is complex, and is the central focus of the following review; we also discuss the recent advances in our understanding of how dense granule effector proteins are trafficked out of the PV.\n                  <\/jats:p>","DOI":"10.1111\/mmi.14679","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T01:49:06Z","timestamp":1609897746000},"page":"466-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Seizing control: How dense granule effector proteins enable\n                    <i>Toxoplasma<\/i>\n                    to take charge"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2973-736X","authenticated-orcid":false,"given":"Michael 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