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We recently reported that, when grown in blood from trauma patients, <jats:italic>P. aeruginosa<\/jats:italic> expression of malonate utilization genes was upregulated. In this study, we explored the role of malonate utilization and its contribution to <jats:italic>P. aeruginosa<\/jats:italic> virulence. We grew <jats:italic>P. aeruginosa<\/jats:italic> strain PA14 in M9 minimal medium containing malonate (MM9) or glycerol (GM9) as a sole carbon source and assessed the effect of the growth on quorum sensing, virulence factors, and antibiotic resistance. Growth of PA14 in MM9, compared to GM9, reduced the production of elastases, rhamnolipids, and pyoverdine; enhanced the production of pyocyanin and catalase; and increased its sensitivity to norfloxacin. Growth in MM9 decreased extracellular levels of <jats:italic>N<\/jats:italic>\u2010acylhomoserine lactone autoinducers, an effect likely associated with increased pH of the culture medium; but had little effect on extracellular levels of PQS. At 18\u00a0hr of growth in MM9, PA14 formed biofilm\u2010like structures or aggregates that were associated with biomineralization, which was related to increased pH of the culture medium. These results suggest that malonate significantly impacts <jats:italic>P. aeruginosa<\/jats:italic> pathogenesis by influencing the quorum sensing systems, the production of virulence factors, biofilm formation, and antibiotic resistance.<\/jats:p>","DOI":"10.1111\/mmi.14729","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T21:46:57Z","timestamp":1619214417000},"page":"516-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Malonate utilization by <i>Pseudomonas aeruginosa<\/i> affects quorum\u2010sensing and virulence and leads to formation of mineralized biofilm\u2010like structures"],"prefix":"10.1111","volume":"116","author":[{"given":"Moamen M.","family":"Elmassry","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Texas Tech University  Lubbock TX 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