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Neutrophils, historically regarded as effector phagocytes that drive host defense via microbial killing, are now emerging as critical drivers of immunity in vivo. Here, we summarize, the latest advancement in inflammasome, gasdermin, and cell death signaling in neutrophils. We discuss the mechanisms by which neutrophils resist caspase\u20101\u2010dependent pyroptosis, the lytic function of gasdermin D and E during NETosis and <jats:italic>Yersinia<\/jats:italic> infection, and the contribution of neutrophil inflammasomes to inflammatory disorders.<\/jats:p>","DOI":"10.1111\/mmi.14891","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T11:43:59Z","timestamp":1646394239000},"page":"961-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inflammasome and gasdermin signaling in neutrophils"],"prefix":"10.1111","volume":"117","author":[{"given":"See Jie","family":"Yow","sequence":"first","affiliation":[{"name":"Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Immunology Programme, Life Sciences Institute National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Wen","family":"Yeap","sequence":"additional","affiliation":[{"name":"Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Immunology Programme, Life Sciences Institute National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5903-3251","authenticated-orcid":false,"given":"Kaiwen W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Immunology Programme, Life Sciences Institute National University of Singapore  Singapore 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