{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:24:43Z","timestamp":1788409483298,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI127652"],"award-info":[{"award-number":["R01AI127652"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI153303"],"award-info":[{"award-number":["R01AI153303"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Satellite viruses are present across all domains of life, defined as subviral parasites that require infection by another virus for satellite progeny production. Phage satellites exhibit various regulatory mechanisms to manipulate phage gene expression to the benefit of the satellite, redirecting resources from the phage to the satellite, and often inhibiting phage progeny production. While small RNAs (sRNAs) are well documented as regulators of prokaryotic gene expression, they have not been shown to play a regulatory role in satellite\u2010phage conflicts.\n                    <jats:italic>Vibrio cholerae<\/jats:italic>\n                    encodes the phage inducible chromosomal island\u2010like element (PLE), a phage satellite, to defend itself against the lytic phage ICP1. Here, we use Hi\u2010GRIL\u2010seq to identify a complex RNA\u2013RNA interactome between PLE and ICP1. Both inter\u2010 and intragenome RNA interactions were detected, headlined by the PLE sRNA, SviR. SviR is involved in regulating both PLE and ICP1 gene expression uniquely, decreasing ICP1 target translation and affecting PLE transcripts. The striking conservation of SviR across all known PLEs suggests the sRNA is deeply rooted in the PLE\u2010ICP1 conflict and implicates sRNAs as unidentified regulators of gene expression in phage\u2013satellite interactions.\n                  <\/jats:p>","DOI":"10.1111\/mmi.15046","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T05:01:12Z","timestamp":1676350872000},"page":"515-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The RNA\u2013RNA interactome between a phage and its satellite virus reveals a small RNA that differentially regulates gene expression across both genomes"],"prefix":"10.1111","volume":"119","author":[{"given":"Drew T.","family":"Dunham","sequence":"first","affiliation":[{"name":"Department of Plant and Microbial Biology University of California, Berkeley  Berkeley California 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