{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:12:08Z","timestamp":1787767928492,"version":"build-2784847793"},"reference-count":343,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102019\u201005490"],"award-info":[{"award-number":["RGPIN\u20102019\u201005490"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102017\u201004970"],"award-info":[{"award-number":["RGPIN\u20102017\u201004970"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Legionella pneumophila<\/jats:italic> is a gram\u2010negative bacteria found in natural and anthropogenic aquatic environments such as evaporative cooling towers, where it reproduces as an intracellular parasite of cohabiting protozoa. If <jats:italic>L. pneumophila<\/jats:italic> is aerosolized and inhaled by a susceptible person, bacteria may colonize their alveolar macrophages causing the opportunistic pneumonia Legionnaires' disease. <jats:italic>L. pneumophila<\/jats:italic> utilizes an elaborate regulatory network to control virulence processes such as the Dot\/Icm Type IV secretion system and effector repertoire, responding to changing nutritional cues as their host becomes depleted. The bacteria subsequently differentiate to a transmissive state that can survive in the environment until a replacement host is encountered and colonized. In this review, we discuss the lifecycle of <jats:italic>L. pneumophila<\/jats:italic> and the molecular regulatory network that senses nutritional depletion via the stringent response, a link to stationary phase\u2010like metabolic changes via alternative sigma factors, and two\u2010component systems that are homologous to stress sensors in other pathogens, to regulate differentiation between the intracellular replicative phase and more transmissible states. Together, we highlight how this prototypic intracellular pathogen offers enormous potential in understanding how molecular mechanisms enable intracellular parasitism and pathogenicity.<\/jats:p>","DOI":"10.1111\/mmi.15172","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T06:02:22Z","timestamp":1698818542000},"page":"167-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Molecular regulation of virulence in <i>Legionella pneumophila<\/i>"],"prefix":"10.1111","volume":"121","author":[{"given":"Christopher I.","family":"Graham","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Science University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teassa L.","family":"MacMartin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Science University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa R.","family":"de\u00a0Kievit","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Science University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Karen C.","family":"Brassinga","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Science University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00732-15"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00595-15"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12300"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141121660"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00038"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242835"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.64.9.3127-3133.1998"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.5.3021-3026.2006"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00785.x"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5339-5349.2005"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000361"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00610-09"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01081-08"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.11.6431-6440.2000"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01493-07"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01401.x"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400060174"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13151"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00454"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.1.177-185.2001"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00401-5"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1200478"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M115.053579"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02465.x"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.5.2468-2476.2004"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.6.3284-3293.2004"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02982.x"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00956-06"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2899-2909.2005"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611030104"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.51.2.422-424.1986"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.12.2684"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05442.x"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01195-08"},{"key":"e_1_2_15_36_1","article-title":"Legionnaires' disease in Europe, 2011 to 2015","volume":"22","author":"Beaut\u00e9 J.","year":"2017","journal-title":"Euro Surveillance"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.00080"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1086\/342903"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01092.x"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01317.x"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01214-07"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.64.1.279-286.1998"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01313-18"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00477"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26261"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.2.668-673.1996"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01316.x"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.15.4630-4637.2003"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00703.x"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.19.6622-6630.2005"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3481"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.7.3029-3034.1998"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwz142"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1447"},{"key":"e_1_2_15_55_1","unstructured":"Centers for Disease Control and Prevention. (2018)Legionnaires' Disease Surveillance Summary Report 2014\u20132015. Available from:https:\/\/www.cdc.gov\/legionella\/health\u2010depts\/surv\u2010reporting\/2014\u201015\u2010surv\u2010report\u2010508.pdf[Accessed 17th November 2020]."},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9020291"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.01.001"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00489-07"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.61.5.1959-1967.1995"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.2003.16.12.1106"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.1998.00190.x"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227026"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz340"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218941"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(00)01792-3"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.9.2912-2918.1990"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.1.121"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00014-17"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.8.3254-3261.1994"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.1.508-517.2001"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.046268-0"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.02176.x"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1505356"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14670"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121286109"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2016.03.022"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.17.5108-5115.1995"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06555.x"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00046-09"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07094.x"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.22.7716-7726.2005"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608279103"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2009.02025.x"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2007.06.001"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01562.x"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.5.3048-3053.2004"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6442a2"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59530"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06593.x"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01107-09"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12326"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2015.11.002"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2015.1"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.07.020"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2011.00060"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00751-08"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.24.7025-7041.2002"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05243.x"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14101"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13290"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4221-00141"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.506-526.2002"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.47.3.467-471.1984"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12450"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb00858.x"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01091-14"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00012"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001289"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2003.12.003"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01546-08"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712012972201"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.16.4908-4919.2003"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0882-4010(03)00027-5"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-2920.2000.00076.x"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2007.01245.x"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.11.6273-6283.2002"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.10.4602-4610.1998"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1139\/w98-023"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-28022-7_6"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02495"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.11.3.286-291.1980"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643598"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0427-4"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0603-6"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.693481"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112517"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evz186"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808016116"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.tb02386.x"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14760"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.1998.63.141"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.479998"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.16.4879-4889.1999"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01519.x"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02884.x"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13313"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170149"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.2001.14.12.1351"},{"key":"e_1_2_15_139_1","first-page":"690","article-title":"Association between Legionella pneumophila and amoebae in water","volume":"22","author":"Henke M.","year":"1986","journal-title":"Israel Journal of Medical Sciences"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4221-00259"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00313"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2020.01.001"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14477"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.45.3.784-791.1983"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00421-12"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.45.1.18-24.1984"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.4.1319"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.2108"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90070-9"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.99.6.1936"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109874"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01578-08"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msac037"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508936102"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1967"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.499"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0055-7"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.65.2.822-827.1999"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621438114"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb883"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.4.2055-2064.1990"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06757.x"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/018135-0"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01175-08"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2307.161429"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2012.02889.x"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.04.033"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1990.tb02904.x"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16397-0"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00680.x"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12951"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.8.2324-2330.2002"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2005.04.003"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.12.3712-3720.2001"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00384"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1404506111"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001216"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl439"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609012103"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2010.12.003"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00141-08"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb856"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.12.028"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.204693.112"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00316-10"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46086"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1869-6"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.3389\/frwa.2022.891477"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1646"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2010.01467.x"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2010.03.004"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1994.tb06798.x"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2011.00036"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0304916101"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(03)00050-8"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00897-16"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.144.7.2738"},{"key":"e_1_2_15_198_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9607"},{"key":"e_1_2_15_199_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.3.4359"},{"key":"e_1_2_15_200_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01077-10"},{"key":"e_1_2_15_201_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-4-659"},{"key":"e_1_2_15_202_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.4.1527-1532.2005"},{"key":"e_1_2_15_203_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjm-2018-0129"},{"key":"e_1_2_15_204_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1581ST"},{"key":"e_1_2_15_205_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.3.970-979.1992"},{"key":"e_1_2_15_206_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.12.4939-4943.1995"},{"key":"e_1_2_15_207_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.5850703"},{"key":"e_1_2_15_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(02)02359-4"},{"key":"e_1_2_15_209_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.1.69-78.2002"},{"key":"e_1_2_15_210_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.7.4040-4051.2004"},{"key":"e_1_2_15_211_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00292-07"},{"key":"e_1_2_15_212_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00335.x"},{"key":"e_1_2_15_213_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03706.x"},{"key":"e_1_2_15_214_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04129.x"},{"key":"e_1_2_15_215_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01201-20"},{"key":"e_1_2_15_216_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02756-08"},{"key":"e_1_2_15_217_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05829-11"},{"key":"e_1_2_15_218_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067025"},{"key":"e_1_2_15_219_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2011.00136"},{"key":"e_1_2_15_220_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.5962"},{"key":"e_1_2_15_221_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb01530.x"},{"key":"e_1_2_15_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52537-6"},{"key":"e_1_2_15_223_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-11-3639"},{"key":"e_1_2_15_224_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01175-13"},{"key":"e_1_2_15_225_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00052-09"},{"key":"e_1_2_15_226_1","doi-asserted-by":"publisher","DOI":"10.33321\/cdi.2021.45.28"},{"key":"e_1_2_15_227_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111678108"},{"key":"e_1_2_15_228_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229556"},{"key":"e_1_2_15_229_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00003"},{"key":"e_1_2_15_230_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02182-16"},{"key":"e_1_2_15_231_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.3.1173"},{"key":"e_1_2_15_232_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03328-19"},{"key":"e_1_2_15_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0663-7"},{"key":"e_1_2_15_234_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.5.1377"},{"key":"e_1_2_15_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(88)90011-3"},{"key":"e_1_2_15_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.030"},{"key":"e_1_2_15_237_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001550200"},{"key":"e_1_2_15_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2017.11.010"},{"key":"e_1_2_15_239_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.23.1.33-42.1986"},{"key":"e_1_2_15_240_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.062117-0"},{"key":"e_1_2_15_241_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.00112"},{"key":"e_1_2_15_242_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.62.081307.162903"},{"key":"e_1_2_15_243_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.67"},{"key":"e_1_2_15_244_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064129"},{"key":"e_1_2_15_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2016.05.012"},{"key":"e_1_2_15_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90101-0"},{"key":"e_1_2_15_247_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06705.x"},{"key":"e_1_2_15_248_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.6.1560-1567.1998"},{"key":"e_1_2_15_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81824-3"},{"key":"e_1_2_15_250_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.24290"},{"key":"e_1_2_15_251_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00670"},{"key":"e_1_2_15_252_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.13.4154-4164.1993"},{"key":"e_1_2_15_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.03.004"},{"key":"e_1_2_15_254_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.15.4744-4755.1993"},{"key":"e_1_2_15_255_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01946-12"},{"key":"e_1_2_15_256_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.4.2092-2098.2001"},{"key":"e_1_2_15_257_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01944-07"},{"key":"e_1_2_15_258_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.310-321.2004"},{"key":"e_1_2_15_259_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.12.1179"},{"key":"e_1_2_15_260_1","first-page":"678","article-title":"Current views on the relationships between amoebae, legionellae and man","volume":"22","author":"Rowbotham T.J.","year":"1986","journal-title":"Israel Journal of Medical Sciences"},{"key":"e_1_2_15_261_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00841.x"},{"key":"e_1_2_15_262_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.2.571-578.1997"},{"key":"e_1_2_15_263_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1745409"},{"key":"e_1_2_15_264_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.12.5361-5373.1993"},{"key":"e_1_2_15_265_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06677.x"},{"key":"e_1_2_15_266_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.20270"},{"key":"e_1_2_15_267_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006629"},{"key":"e_1_2_15_268_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026028930203"},{"key":"e_1_2_15_269_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14644"},{"key":"e_1_2_15_270_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02975-20"},{"key":"e_1_2_15_271_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502767102"},{"key":"e_1_2_15_272_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12612"},{"key":"e_1_2_15_273_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13265"},{"key":"e_1_2_15_274_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00528"},{"key":"e_1_2_15_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsre.2004.07.001"},{"key":"e_1_2_15_276_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01642.x"},{"key":"e_1_2_15_277_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02645.x"},{"key":"e_1_2_15_278_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.5.2117-2124.1999"},{"key":"e_1_2_15_279_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12403-017-0255-9"},{"key":"e_1_2_15_280_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010720"},{"key":"e_1_2_15_281_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01301.x"},{"key":"e_1_2_15_282_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b04754"},{"key":"e_1_2_15_283_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-102215-095557"},{"key":"e_1_2_15_284_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2005.09.003"},{"key":"e_1_2_15_285_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2311.170137"},{"key":"e_1_2_15_286_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjm-2015-0166"},{"key":"e_1_2_15_287_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820093116"},{"key":"e_1_2_15_288_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00121-17"},{"key":"e_1_2_15_289_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801929200"},{"key":"e_1_2_15_290_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.56.1.49-53.1990"},{"key":"e_1_2_15_291_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.61.6.2428-2430.1995"},{"key":"e_1_2_15_292_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050560"},{"key":"e_1_2_15_293_1","doi-asserted-by":"publisher","DOI":"10.1038\/338266a0"},{"key":"e_1_2_15_294_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.4.1768-1775.1998"},{"key":"e_1_2_15_295_1","doi-asserted-by":"publisher","DOI":"10.2166\/wst.2004.0023"},{"key":"e_1_2_15_296_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.9.3609-3620.1995"},{"key":"e_1_2_15_297_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.7.2585-2594.1996"},{"key":"e_1_2_15_298_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00061"},{"key":"e_1_2_15_299_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00025"},{"key":"e_1_2_15_300_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.4.589"},{"key":"e_1_2_15_301_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13365"},{"key":"e_1_2_15_302_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00690-16"},{"key":"e_1_2_15_303_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.9.4016-4021.2003"},{"key":"e_1_2_15_304_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.154.3.1104-1109.1983"},{"key":"e_1_2_15_305_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/138.4.512"},{"key":"e_1_2_15_306_1","doi-asserted-by":"publisher","DOI":"10.3390\/s120302899"},{"key":"e_1_2_15_307_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01002-08"},{"key":"e_1_2_15_308_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2010.02167.x"},{"key":"e_1_2_15_309_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.01005.x"},{"key":"e_1_2_15_310_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00703.x"},{"key":"e_1_2_15_311_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-6-112"},{"key":"e_1_2_15_312_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03132-14"},{"key":"e_1_2_15_313_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00870-17"},{"key":"e_1_2_15_314_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-4-509"},{"key":"e_1_2_15_315_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00045-13"},{"key":"e_1_2_15_316_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.3.1163"},{"key":"e_1_2_15_317_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00440.x"},{"key":"e_1_2_15_318_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2016.02.003"},{"key":"e_1_2_15_319_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20167381"},{"key":"e_1_2_15_320_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00052-14"},{"key":"e_1_2_15_321_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-020518-115555"},{"key":"e_1_2_15_322_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2021.126775"},{"key":"e_1_2_15_323_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.4.537"},{"key":"e_1_2_15_324_1","first-page":"643","article-title":"Opsonization of Legionella pneumophila in human serum: key roles for specific antibodies and the classical complement pathway","volume":"54","author":"Verbrugh H.A.","year":"1985","journal-title":"Immunology"},{"key":"e_1_2_15_325_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.06238-11"},{"key":"e_1_2_15_326_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06177.x"},{"key":"e_1_2_15_327_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00802.x"},{"key":"e_1_2_15_328_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02420-18"},{"key":"e_1_2_15_329_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082221"},{"key":"e_1_2_15_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2022.100105"},{"key":"e_1_2_15_331_1","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000273"},{"key":"e_1_2_15_332_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00528-18"},{"key":"e_1_2_15_333_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00374-19"},{"key":"e_1_2_15_334_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.9.4450-4460.1998"},{"key":"e_1_2_15_335_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2016.12.015"},{"key":"e_1_2_15_336_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00092-1"},{"key":"e_1_2_15_337_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.58.4.1394-1397.1992"},{"key":"e_1_2_15_338_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23905"},{"key":"e_1_2_15_339_1","doi-asserted-by":"publisher","DOI":"10.1086\/341087"},{"key":"e_1_2_15_340_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017638"},{"key":"e_1_2_15_341_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.08.003"},{"key":"e_1_2_15_342_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06415.x"},{"key":"e_1_2_15_343_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05604.x"},{"key":"e_1_2_15_344_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.1.67-75.2002"}],"container-title":["Molecular Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mmi.15172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T20:36:35Z","timestamp":1707510995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mmi.15172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":343,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/mmi.15172"],"URL":"https:\/\/doi.org\/10.1111\/mmi.15172","archive":["Portico"],"relation":{},"ISSN":["0950-382X","1365-2958"],"issn-type":[{"value":"0950-382X","type":"print"},{"value":"1365-2958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,31]]},"assertion":[{"value":"2023-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}