{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:18Z","timestamp":1787015778522,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AI154726"],"award-info":[{"award-number":["R21 AI154726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM136644"],"award-info":[{"award-number":["R35 GM136644"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pathogenic fungi must appropriately sense the host availability of essential metals such as Fe. In\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and other yeasts, sensing of Fe involves mitochondrial Fe\u2010S clusters. Yeast mutants for Fe\u2010S cluster assembly sense Fe limitation even when Fe is abundant and hyperaccumulate Fe. We observe this same disrupted Fe sensing with\n                    <jats:italic>C. albicans<\/jats:italic>\n                    mutants of SMF11, a NRAMP transporter of divalent metals. Mutants of\n                    <jats:italic>smf11<\/jats:italic>\n                    hyperaccumulate both Mn and Fe and the elevated Mn is secondary to Fe overload. As with Fe\u2010S biogenesis mutants,\n                    <jats:italic>smf11\u2206\/\u2206<\/jats:italic>\n                    mutants show upregulation of ferric reductases that are normally repressed under high Fe, and Fe import is activated. However, unlike Fe\u2010S biogenesis mutants,\n                    <jats:italic>smf11\u2206\/\u2206<\/jats:italic>\n                    mutants show no defects in mitochondrial Fe\u2010S enzymes. Intriguingly, this exact condition of disrupted Fe sensing without inhibiting Fe\u2010S clusters occurs with\n                    <jats:italic>C. albicans fre1\u2206\/\u2206<\/jats:italic>\n                    mutants encoding a ferric reductase. Mutants of\n                    <jats:italic>fre1<\/jats:italic>\n                    and\n                    <jats:italic>smf11<\/jats:italic>\n                    display similar perturbations in the cell wall, in filamentation and in the ROS burst of morphogenesis, a Fe\u2010dependent process. As with FRE1, SMF11 is important for virulence in a mouse model for disseminated candidiasis. We propose a model in which FRE1 and SMF11 operate outside the mitochondrial Fe\u2010S pathway to donate ferrous Fe for Fe sensing.\n                  <\/jats:p>","DOI":"10.1111\/mmi.15326","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:49:49Z","timestamp":1731372589000},"page":"879-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Converging Roles of the Metal Transporter\n                    <scp>SMF11<\/scp>\n                    and the Ferric Reductase\n                    <scp>FRE1<\/scp>\n                    in Iron Homeostasis of\n                    <i>Candida albicans<\/i>"],"prefix":"10.1111","volume":"122","author":[{"given":"Naisargi K.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Johns Hopkins University Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika S.","family":"David","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Johns Hopkins University Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Johns Hopkins University Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Johns Hopkins University Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology 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