{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:17:38Z","timestamp":1790745458536,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AI169840\u201001A1"],"award-info":[{"award-number":["U01 AI169840\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI151597\u201001"],"award-info":[{"award-number":["R01 AI151597\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    BosR is a novel nucleic acid\u2010binding protein in the ferric uptake regulator (FUR) family that regulates gene expression in the Lyme disease spirochete\n                    <jats:italic>Borrelia<\/jats:italic>\n                    (\n                    <jats:italic>Borreliella<\/jats:italic>\n                    )\n                    <jats:italic>burgdorferi<\/jats:italic>\n                    . This issue of\n                    <jats:italic>Molecular Microbiology<\/jats:italic>\n                    contains a comprehensive transcriptomic study that keenly defines the regulatory swath of BosR in the vertebrate host of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B. burgdorferi<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Despite homology to Fur\u2010like and PurR\u2010like orthologs, BosR has traditionally been linked to regulation of RpoS, the alternative sigma factor that controls the regulon required for establishing a vertebrate infection. However, BosR regulates other genes through an RpoS\u2010independent mechanism, which is elegantly elaborated in Grassmann et\u00a0al., along with clearly demonstrating that BosR does not participate in the defense against oxidative and nitrosative stress in the vertebrate. However, the recently recognized role of BosR as an RNA\u2010binding protein with RNA chaperone activity that regulates gene expression in a post\u2010transcriptional fashion is not wholly appreciated, which clouds the results on determining the DNA\u2010binding site in\u00a0vivo. Regardless, this seminal study enshrines BosR as a major regulator of gene expression in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B. burgdorferi<\/jats:italic>\n                    <\/jats:styled-content>\n                    and delineates a multitude of BosR\u2010regulated cellular functions in the spirochete related to its ability to navigate between its tick vector and vertebrate host in nature as well as to persist in these two disparate environments.\n                  <\/jats:p>","DOI":"10.1111\/mmi.70046","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T11:26:37Z","timestamp":1767353197000},"page":"81-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The\n                    <scp>BosR<\/scp>\n                    Is Back!"],"prefix":"10.1111","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-7593","authenticated-orcid":false,"given":"D. Scott","family":"Samuels","sequence":"first","affiliation":[{"name":"Division of Biological and Biomedical Sciences University of Montana  Missoula Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan C.","family":"Lybecker","sequence":"additional","affiliation":[{"name":"Bacterial Diseases Branch, Division of Vector\u2010Borne Diseases National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2325"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-020518-115907"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00410-08"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198303313081302"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2032956100"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7043737"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12609"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01923"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05860.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010385"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.16.4771-4778.2001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.23.7308-7313.1999"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012122"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2006.11.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.1.435-441.2006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1231043100"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/37551"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13092183"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.70036"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI166710"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306845101"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01204-17"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002133"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231442498"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28996-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06951.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01018-09"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12882"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000166"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.19.6443-6456.2004"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07374.x"},{"key":"e_1_2_7_33_1","first-page":"317","article-title":"Small RNAs of \n                     Borrelia burgdorferi\n                  : Characterizing Functional Regulators in a Sea of sRNAs","volume":"90","author":"Lybecker M. 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