{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:54:50Z","timestamp":1777596890287,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Peptidoglycan synthesis and degradation are both essential for bacterial growth, and damaged peptidoglycan must be continuously repaired. In\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    , peptidoglycan required for cell elongation is synthesized by the Rod complex. Although RodZ is a non\u2010essential component of this complex, its dysfunction leads to aberrant peptidoglycan synthesis, resulting in defects in cell shape and impaired growth. We previously isolated several suppressor mutants that restore growth in cells with impaired RodZ function (RMR cells). Most suppressor mutations mapped to components in the Rod complex other than RodZ. However, one suppressor mutation was identified in\n                    <jats:italic>sanA<\/jats:italic>\n                    , a gene not previously associated with the Rod complex. This mutation,\n                    <jats:italic>sanA<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>M27R<\/jats:italic>\n                    <\/jats:sup>\n                    , represents a loss\u2010of\u2010function allele. Here, we show that SanA is associated with PBP1B, a non\u2010essential yet physiologically important peptidoglycan synthase. Loss of SanA function partially restored the growth of RMR cells, accompanied by enhanced peptidoglycan synthesis and alleviation of structural defects in the cell wall. These findings indicate that SanA contributes to the regulation of peptidoglycan synthesis and cell wall integrity, potentially through functional interplay with PBP1B\u2010dependent pathways.\n                  <\/jats:p>","DOI":"10.1111\/mmi.70058","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:45:06Z","timestamp":1771649106000},"page":"343-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>SanA<\/scp>\n                    Plays a Role in Peptidoglycan Integrity in\n                    <i>Escherichia coli<\/i>"],"prefix":"10.1111","volume":"125","author":[{"given":"Honoka","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Life Science, College of Science Rikkyo University  Toshima Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Ago","sequence":"additional","affiliation":[{"name":"Department of Life Science, College of Science Rikkyo University  Toshima Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhei O.","family":"Tahara","sequence":"additional","affiliation":[{"name":"Graduate School of Science Osaka Metropolitan University  Osaka Japan"},{"name":"The OMU Advanced Research Center for Natural Science and Technology Osaka Metropolitan University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Life Science, College of Science Rikkyo University  Toshima Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Niki","sequence":"additional","affiliation":[{"name":"Microbial Physiology Laboratory, Department of Gene Function and Phenomics National Institute of Genetics  Mishima Shizuoka Japan"},{"name":"Department of Genetics The Graduate University for Advanced Studies SOKENDAI  Mishima Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Miyata","sequence":"additional","affiliation":[{"name":"Graduate School of Science Osaka Metropolitan University  Osaka Japan"},{"name":"The OMU Advanced Research Center for Natural Science and Technology Osaka Metropolitan University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Department of Life Science, College of Science Rikkyo University  Toshima Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.1385"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1340143"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16066"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2016.05.006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100050"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08103.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01322-07"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.264"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05280.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015951"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1994.tb07077.x"},{"key":"e_1_2_11_13_1","article-title":"Impaired Envelope Integrity in the Absence of SanA Is Linked to Increased Lipid II Availability and an Imbalance of FtsI and FtsW Activities","author":"Carr J. 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