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Fluorescent labeling of the plasma membrane of\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    , the causative agent of malaria, via membrane\u2010resident proteins has been described, but proteins that broadly mark internal membranes are currently elusive. Alternatively, general membrane dyes can be employed to study membrane dynamics; however, we find that the membrane dye BODIPY TR Ceramide has adverse effects on cell viability during live\u2010cell imaging. To overcome this limitation, we present IMMP (Internal Membrane Marker for\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    ), a 32\u2010amino acid long peptide derived from\n                    <jats:italic>P.\u2009falciparum<\/jats:italic>\n                    PCNA1, which targets (fluorescent) protein tags to internal membranes for detection in live or fixed samples. Importantly, IMMP enables non\u2010invasive, long\u2010term live\u2010cell imaging of internal membranes without affecting\n                    <jats:italic>P.\u2009falciparum<\/jats:italic>\n                    viability and is functional in blood stages of both the human malaria parasite\n                    <jats:italic>P.\u2009falciparum<\/jats:italic>\n                    and the rodent\u2010infecting parasite\n                    <jats:italic>P.\u2009berghei<\/jats:italic>\n                    , as well as in\n                    <jats:italic>P.\u2009berghei<\/jats:italic>\n                    mosquito stages. IMMP is also compatible with advanced techniques such as expansion microscopy. Together, our results establish IMMP as a tool for internal membrane imaging in\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/mmi.70098","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:55:46Z","timestamp":1789469746000},"page":"462-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Genetically Encoded Marker for Imaging of Internal\n                    <i>Plasmodium<\/i>\n                    Membranes"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7687-4009","authenticated-orcid":false,"given":"Leah","family":"Zink","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases, Parasitology, Medical Faculty Heidelberg Heidelberg University  Heidelberg 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